| Locally synthesized HSP27 in hepatocytes: Is it possibly a novel strategy against human liver ischemia/reperfusion injury? | |
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MedLine Citation:
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PMID: 21067867 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Ischemia/reperfusion injury (IRI) is a common complication after liver surgery. Approximately 10% of grafts lose function in the early stage after liver transplantation. However, there is no effective way against IRI yet. Heat shock protein 27 (HSP27), a member of the heat shock protein families, is recognized as a protective factor against liver IRI recently. Studies showed that HSP27 can lessen the induction of proinflammatory messenger, reduce neutrophil infiltration, decrease apoptosis (caspase 3 fragmentation and DNA laddering), and reduce disruption of filamentous actin. In addition, Kupffer cells inhibitor- gadolinium chloride can reduce lipid peroxidation and promote hepatocytes regeneration. Herein, we hypothesize that transfecting liver with HSP27 gene accompanied by gadolinium chloride might be a potentially novel treatment against IRI. Compared to passive defense, we firstly suggest positive protection against ischemia/reperfusion injury by hepatocytes automatically. |
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Authors:
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Sun-Yi Ye; Jian Wu; Jun Zhang; Shu-Sen Zheng |
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Publication Detail:
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Type: Journal Article Date: 2010-11-09 |
Journal Detail:
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Title: Medical hypotheses Volume: 76 ISSN: 1532-2777 ISO Abbreviation: Med. Hypotheses Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: United States |
Other Details:
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Languages: eng Pagination: 296-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Key Laboratory of Combined Multi-Organ Transplantation, Minstry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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