Document Detail

Locally and reflexly mediated effects of cholecystokinin-octapeptide on the ferret stomach.
MedLine Citation:
PMID:  1765619     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to investigate the site of origin of vagal reflexes which cholecystokinin (CCK) activates to cause reflex inhibition of gastric motility. In the anaesthetized ferret, close intraarterial injections of CCK-8 (100 pmol) caused a short latency increase in duodenal contractile activity; antral motor responses to CCK were variable, often comprising excitation followed by inhibition. The corpus, in contrast, consistently showed a decrease in pressure which lasted 2-3 min before returning to prestimulus levels. Similar responses to CCK-8 were seen in guanethidine (5 mg/kg) treated preparations, indicating that release of noradrenaline was not responsible for the relaxatory responses observed. After bilateral cervical vagotomy the duodenal response was unchanged, but the antrum showed consistent monophasic increases in tone. The response of the corpus was reversed to one of excitation, which was significantly different from prevagotomy responses (P less than 0.0001). In 10 experiments, corpus responses to CCK were tested after removal of the intestine and again after removal of the antrum. Upon removal of these segments the inhibitory motor response to CCK was reversed to one of excitation (P less than 0.01). Corpus relaxation in response to duodenal distension was significantly smaller (P less than 0.05) than that to CCK despite higher duodenal pressures during distension. Minimizing intraantral pressure changes by means of an isotonic reservoir system did not affect the response of the corpus to CCK administration. The data indicate that the inhibition of gastric motility by CCK is mediated by a direct vagal reflex and is not secondary to motility changes.(ABSTRACT TRUNCATED AT 250 WORDS)
L A Blackshaw; D Grundy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  36     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-02-18     Completed Date:  1992-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  129-37     Citation Subset:  IM; S    
Department of Biomedical Science, The University, Sheffield, U.K.
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MeSH Terms
Duodenum / drug effects
Gastrointestinal Motility / drug effects
Mechanoreceptors / physiology
Muscle Relaxation
Pyloric Antrum / drug effects
Reflex / physiology*
Sincalide / pharmacology*
Stomach / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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