Document Detail

Locally elevated leukemia inhibitory factor in the inflamed fallopian tube resembles that found in tubal pregnancy.
MedLine Citation:
PMID:  18468598     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the association between the expressions of leukemia inhibitory factor and the occurrence of tubal pregnancy. DESIGN: Prospective observational study. SETTING: University-based obstetrics and gynecology hospital. PATIENT(S): Thirty women undergoing salpingectomy for tubal pregnancy and 30 nonpregnant patients with benign uterine or appendix disease. INTERVENTION(S): Oviduct tissues with ectopic gestation were separated into implantation sites and nonimplantation sites. Samples of ampullary fallopian tubes during midsecretory phase were collected as control groups. Immunohistochemical and Western blot analysis were performed. MAIN OUTCOME MEASURE(S): The differences of leukemia inhibitory factor expression between the implantation and nonimplantation sites of oviduct tissues and the normal and chronically inflamed fallopian tubes. RESULT(S): The expression of leukemia inhibitory factor in the implantation group is significantly higher than that in the nonimplantation group or in the normal group. A statistically significant difference was also found for leukemia inhibitory factor between the chronic inflammation group and the normal group by Western blot analysis but no difference between the chronic inflammation group and the implantation group or the nonimplantation group. CONCLUSION(S): Leukemia inhibitory factor might be one of the reasons that cause patients with salpingitis to be more susceptible to tubal pregnancy and might be involved in the implantation process of tubal pregnancy.
Yin Fen Ji; Li You Chen; Kai Hong Xu; Ji Fen Yao; Yi Fu Shi
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Publication Detail:
Type:  Journal Article     Date:  2008-05-12
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2308-14     Citation Subset:  IM    
Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
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MeSH Terms
Embryo Implantation
Fallopian Tubes / metabolism,  pathology,  physiopathology*
Inflammation / metabolism
Leukemia Inhibitory Factor / metabolism*
Pregnancy, Ectopic / metabolism,  physiopathology,  surgery*
Pregnancy, Tubal / metabolism,  surgery*
Salpingitis / metabolism,  surgery
Young Adult
Reg. No./Substance:
0/LIF protein, human; 0/Leukemia Inhibitory Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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