| Locally delivered doxycycline as an adjunctive therapy to scaling and root planing in the treatment of smokers: a 2-year follow-up. | |
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MedLine Citation:
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PMID: 16584341 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this clinical study was to evaluate the association of locally delivered doxycycline 10% with scaling and root planing in the periodontal treatment of smokers during a 2-year period. METHODS: Forty-eight chronic periodontitis patients, presenting a minimum of four pockets (>or=5 mm) that bled on probing on anterior teeth were included. Patients were randomly assigned to receive one of the following treatments: scaling and root planing (SRP) and scaling and root planing followed by local application of doxycycline (SRP-D). Assigned treatments were performed at baseline and at 12 months. Clinical parameters, including probing depth (PD) and relative attachment level (RAL), were recorded at baseline; 45 days; 3, 6, and 12 months (retreatment); 45 days following retreatment; and at 15, 18, and 24 months. RESULTS: In initially deep pockets (>or=7 mm), SRP-D showed greater PD reduction than SRP at 6 and 18 months (mean difference between groups of 1.18 and 1.73 mm, respectively; P <0.05) and greater RAL gain in all periods after 3 months (mean difference between groups of 1.16, 1.99, and 1.78 mm, at 6, 18, and 24 months, respectively; P <0.05). Also, the proportion of sites showing >or=2 mm PD reduction was greater for SRP-D at 6 months (81.2% x 50.8%; P <0.001) and at 24 months (65.5% x 46.5%; P = 0.01). As for RAL gain, this proportion was 34.4% and 18.1% for SRP-D and SRP at 24 months, respectively (P = 0.008). CONCLUSION: The use of locally delivered doxycycline may constitute an important adjunct for the active and supportive treatments of severe periodontal disease in smokers. |
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Authors:
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Luciana Machion; Denise Carleto Andia; Giovana Lecio; Francisco Humberto Nociti; Márcio Zaffalon Casati; Antonio Wilson Sallum; Enilson Antonio Sallum |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of periodontology Volume: 77 ISSN: 0022-3492 ISO Abbreviation: J. Periodontol. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-04 Completed Date: 2006-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: United States |
Other Details:
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Languages: eng Pagination: 606-13 Citation Subset: D; IM |
Affiliation:
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Department of Periodontics and Prosthodontics, School of Dentistry at Piracicaba, State University of Campinas, São Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Anti-Infective Agents, Local / administration & dosage* Chronic Disease Combined Modality Therapy Dental Plaque Index Dental Scaling* Doxycycline / administration & dosage* Female Follow-Up Studies Gingival Recession / drug therapy Humans Male Periodontal Attachment Loss / drug therapy Periodontal Index Periodontitis / drug therapy* Prospective Studies Single-Blind Method Smoking* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 564-25-0/Doxycycline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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