Document Detail


Locally advanced breast cancer.
MedLine Citation:
PMID:  21594409     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In vitro studies suggest p53 and bcl-2 may be important in the apoptotic response to irradiation, and that rapidly proliferating cells are more sensitive to radiotherapy. The clinical relevance of biological factors in predicting radiotherapy response was investigated in 62 patients with locally advanced breast cancer. Immunocytochemical staining for p53 protein, BCL-2 protein and MIB 1 antigen on the primary tumour, showed that none of these factors significantly predicted radiotherapy response (BCL-2 p=0.45, p53 p=1.0, MIB 1 p=0.92) and appear to be of no clinical value. A semi-quantitative assessment of MIB 1 staining showed a reduction in positive cells following radiotherapy (p=0.04), consistent with a reduced proliferation associated with response.
Authors:
P Willsher; N Kapucuoglu; I Ellis; S Chan; R Blamey; J Robertson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  3     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  1996 May 
Date Detail:
Created Date:  2011-05-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  545-7     Citation Subset:  -    
Affiliation:
CITY HOSP,DEPT HISTOPATHOL,NOTTINGHAM NG5 1PB,ENGLAND. CITY HOSP,DEPT CLIN ONCOL,NOTTINGHAM NG5 1PB,ENGLAND.
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