Document Detail


Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level.
MedLine Citation:
PMID:  18719123     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using synchrotron x-ray fluorescence mapping, we have examined the uptake and localization of organic mercury in zebrafish larvae. Strikingly, the greatest accumulation of methyl and ethyl mercury compounds was highly localized in the rapidly dividing lens epithelium, with lower levels going to brain, optic nerve, and various other organs. The data suggest that the reported impairment of visual processes by mercury may arise not only from previously reported neurological effects, but also from direct effects on the ocular tissue. This novel approach is a powerful tool for directly investigating the molecular toxicology of heavy metals, and should be equally applicable to the study of a wide range of elements in developing embryos.
Authors:
Malgorzata Korbas; Scott R Blechinger; Patrick H Krone; Ingrid J Pickering; Graham N George
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-08-21
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  105     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-27     Completed Date:  2008-10-24     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12108-12     Citation Subset:  IM    
Affiliation:
Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Brain / metabolism
Ethylmercury Compounds
Larva / metabolism*
Lens, Crystalline / metabolism
Methylmercury Compounds
Optic Nerve / metabolism
Organomercury Compounds / analysis,  metabolism,  pharmacokinetics*
Spectrometry, X-Ray Emission
Tissue Distribution
Water Pollutants, Chemical / pharmacokinetics
Zebrafish
Chemical
Reg. No./Substance:
0/Ethylmercury Compounds; 0/Methylmercury Compounds; 0/Organomercury Compounds; 0/Water Pollutants, Chemical
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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