| Localized scleroderma: a series of 52 patients. | |
| | |
MedLine Citation:
|
PMID: 19393504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Localized scleroderma also called morphea is a skin disorder of undetermined cause. The widely recognized Mayo Clinic Classification identifies 5 main morphea types: plaque, generalized, bullous, linear and deep. Whether each of these distinct types has a particular clinical course or is associated with some patient-related features is still unclear. METHODS: We report here a retrospective series of patients with localized scleroderma with an attempt to identify features related to the type of lesion involved. The medical records of all patients with a diagnosis of localized scleroderma were reviewed by skilled practitioners. Lesions were classified according to the Mayo Clinic Classification. The relationship between each lesion type and various clinical features was tested by non-parametrical methods. RESULTS: The sample of 52 patients included 43 females and 9 males. Median age at onset was 30 y (range 1-76). Frequencies of patients according to morphea types were: plaque morphea 41 (78.8%) (including morphea en plaque 30 (57.7%) and atrophoderma of Pasini-Pierini 11 (21.1%)), linear scleroderma 14 (26.9%). Nine patients (17.3%) had both types of localized scleroderma. Median age at onset was lower in patients with linear scleroderma (8 y (range 3-44)) than in others (36 y (range 1-77)) (p=0.0003). Head involvement was more common in patients with linear scleroderma (37.5%) than in other subtypes (11.1%) (p=0.05). Atrophoderma of Pasini-Pierini was never located at the head. Systemic symptoms, antinuclear antibodies and the rheumatic factor were not associated with localized scleroderma types or subtypes. CONCLUSION: These results suggest that morphea types, in adults are not associated with distinct patient features except for age at disease onset (lower) and the localization on the head (more frequent), in patients with lesions of the linear type. |
| | |
Authors:
|
C Toledano; S Rabhi; A Kettaneh; B Fabre; L Fardet; K P Tiev; J Cabane |
Related Documents
:
|
6164224 - Studies on gastrointestinal plasma protein loss in extensive skin disease. 8080004 - Clinical features and course of kaposi's sarcoma in kidney transplant patients: report ... 9892904 - The measurement of constitutive and facultative skin pigmentation and estimation of sun... 20826074 - Absence of small-vessel abnormalities in alternating hemiplegia of childhood. 23183474 - 16s rdna-based metagenomic analysis of human oral plaque microbiota in patients with at... 11818094 - Residual and recurrent lesions after conization for cervical intraepithelial neoplasia ... |
Publication Detail:
|
Type: Journal Article Date: 2008-09-17 |
Journal Detail:
|
Title: European journal of internal medicine Volume: 20 ISSN: 1879-0828 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-27 Completed Date: 2009-07-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 331-6 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine Centre Hospitalo-Universitaire Saint-Antoine, 75012 Paris, Assistance Publique/Hôpitaux de Paris, France. cecile.toledano@sat.ap-hop-paris.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Age of Onset Aged Child Child, Preschool Female Fibrosis Humans Infant Male Middle Aged Retrospective Studies Scleroderma, Localized / classification*, drug therapy, pathology* Skin / pathology* Steroids / therapeutic use Subcutaneous Tissue / pathology Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A French national research project to the creation of an auscultation's school: the ASAP project.
Next Document: Magnetic compression biliary-enteric anastomosis for palliation of obstructive jaundice: initial cli...