Document Detail


Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.
MedLine Citation:
PMID:  15554737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glatiramer acetate (copolymer 1, Copaxone) is a mixture of synthetic polypeptides and is used for the treatment of multiple sclerosis. It has been shown to possess beneficial effects in reducing the relapse rate in relapsing-remitting multiple sclerosis. Its main mechanism of action is regarded as a switch of the immune reaction from a T helper (Th)1 to a Th2 cell type. Glatiramer acetate is administered by subcutaneous injection once daily. As described in previous reports, the most common adverse effects are pain, inflammation, and induration at the injection site, occurring in approximately 20-60% of patients. A rare adverse effect is a localized lipoatrophy at the site of injection, which has previously been observed and described in 11 patients. It has been reported that these atrophic areas remain unchanged and localized lipoatrophy may be preceded by a subcutaneous panniculitis. In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.
Authors:
Noemi Soós; Kaweh Shakery; Ulrich Mrowietz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of clinical dermatology     Volume:  5     ISSN:  1175-0561     ISO Abbreviation:  Am J Clin Dermatol     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-23     Completed Date:  2005-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100895290     Medline TA:  Am J Clin Dermatol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  357-9     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of Kiel, Kiel, Germany. umroweitz@dermatology.uni-kiel.de
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MeSH Terms
Descriptor/Qualifier:
Dose-Response Relationship, Drug
Female
Humans
Immunosuppressive Agents / administration & dosage,  adverse effects*
Injections, Subcutaneous
Lipodystrophy / chemically induced*,  drug therapy
Middle Aged
Multiple Sclerosis, Relapsing-Remitting / drug therapy*,  physiopathology
Panniculitis / chemically induced*,  drug therapy
Peptides / administration & dosage,  adverse effects*
Risk Factors
Time Factors
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Peptides; 0/copolymer 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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