| Localized measurement of atherosclerotic plaque inflammatory burden with dynamic contrast-enhanced MRI. | |
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MedLine Citation:
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PMID: 20665799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammation plays an important role in progression and rupture of atherosclerotic plaque. Dynamic contrast-enhanced MRI has been proposed as a tool to evaluate inflammation in vivo by measuring the transfer constant and partial plasma volume, which are influenced by inflammation. This study sought to demonstrate the ability of dynamic contrast-enhanced MRI to provide localized measurements of transfer constant and partial plasma volume within plaque regions of different compositions. In order to do that, a highly automatic procedure for localized measurement of dynamic contrast-enhanced MRI parameters was developed. In 47 subjects, the average transfer constant and partial plasma volume were highest in loose matrix and fibrous tissue and substantially lower in intraplaque hemorrhage, lipid rich/necrotic core, and calcification. In addition, except for hemorrhage and calcification, statistically significant differences of transfer constant and partial plasma volume were observed for any pair of these components. This suggests that transfer constant and partial plasma volume could be helpful to differentiate different plaque components and that dynamic contrast-enhanced MRI has the potential to assess inflammatory burden in specific regions. |
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Authors:
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Huijun Chen; Jianming Cai; Xihai Zhao; Hunter Underhill; Hideki Ota; Minako Oikawa; Li Dong; Chun Yuan; William S Kerwin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 567-73 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Washington, Seattle, Washington, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arteritis
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complications*,
pathology* Atherosclerosis / complications*, pathology* Contrast Media* Female Humans Magnetic Resonance Imaging / methods* Middle Aged Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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