Document Detail

Localized intradermal microinjection of tranexamic acid for treatment of melasma in Asian patients: a preliminary clinical trial.
MedLine Citation:
PMID:  16706756     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Melasma is a common cosmetic problem among Asians. While various treatments are currently being used, there is no entirely satisfactory treatment. It was recently reported that the topical plasmin inhibitor is an effective treatment for ultraviolet-induced hyperpigmentation. OBJECTIVE: Because there are no studies assessing the efficacy and safety of localized microinjection of tranexamic acid (TA) for the treatment of melasma, we conducted a pilot study to evaluate the efficacy and side effects of this potentially new method for the treatment of melasma in Korean women. METHODS: A total of 100 women with melasma, after written consent, were enrolled for a prospective open pilot study of 12 weeks. After applying topical anesthesia, 0.05 mL TA (4 mg/mL) was injected intradermally into the melasma lesion at 1 cm intervals by using a 0.5 mL insulin syringe with a 30-gauge needle. This was repeated weekly for 12 weeks. A clinical investigator evaluated the results by using the Melasma Area and Severity Index (MASI) at baseline and at 4, 8, and 12 weeks. The patient satisfaction questionnaire was documented at 12 weeks. Safety evaluations were performed at each follow-up visit. RESULTS: Eighty-five patients completed the trial. A significant decrease in the MASI from baseline to 8 and 12 weeks was observed (13.22+/-3.02 vs 9.02+/-2.62 at week 8 and vs. 7.57+/-2.54 at week 12; p<.05 for both). The patients' self-assessment of melasma improvement was as follows: 8 of 85 patients (9.4%) rated as good (51-75% lightening), 65 patients (76.5%) as fair (26-50% lightening), and 12 patients (14.1%) as poor (0-25% lightening). Side effects were minimal and all the patients tolerated the treatment well. CONCLUSION: Based on these results, we suggest that the intralesional localized microinjection of TA acid can be used as a potentially new, effective, and safe therapeutic modality for the treatment of melasma.
Ji Ho Lee; Jong Gap Park; Sook Hee Lim; Jo Yong Kim; Kun Young Ahn; Mi-Yeon Kim; Young Min Park
Related Documents :
3989026 - Topical photochemotherapy for alopecia areata.
12745596 - Reversal of photodamage with topical growth factors: a pilot study.
3809266 - The office treatment of tattoos: a simple and effective method.
22246336 - Simultaneous folate intake may prevent advers effect of valproic acid on neurulating ne...
25113666 - The palmar approach for pip-arthroplasty according to simmen: results after 8 years fo...
8677496 - The safety and efficacy of chronically implanted subdural electrodes: a prospective study.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  32     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-18     Completed Date:  2006-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  626-31     Citation Subset:  IM    
Gowoonsesang Dermatology Clinic, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antifibrinolytic Agents / administration & dosage*
Injections, Intradermal
Melanosis / drug therapy*
Middle Aged
Pilot Projects
Prospective Studies
Tranexamic Acid / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Antifibrinolytic Agents; 1197-18-8/Tranexamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Improvement in the appearance of wrinkles with topical transforming growth factor beta(1) and l-asco...
Next Document:  Extended monitoring of hemostatic activation after varicose vein surgery under general anesthesia.