Document Detail


Localized drug delivery in atherosclerotic arteries via a new balloon angioplasty catheter with intramural channels for simultaneous local drug delivery.
MedLine Citation:
PMID:  7497498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A dual-purpose angioplasty catheter with intramural channels and exterior pores for local drug delivery ("channeled balloon") was studied in eight atherosclerotic human necropsy arteries and in 22 rabbits with atherosclerotic peripheral arteries, in which markers (0.005 microns to 15 microns) were infused locally at 2 atmospheres during simultaneous angioplasty at 6 atmospheres. Thirteen of the rabbits were sacrificed at 4 or 24 h after procedure to determine the intramural retention over time. Histology confirmed effective angioplasty and revealed presence of markers in the arterial wall in 29 of 43 treated arteries (67%), whereas all control segments without local delivery had no marker staining. majority of the ineffective local delivery (12/14) occurred when 15 micron particles were infused (12/13 arteries without intramural markers), especially when examined 4 or 24 h later. Thus, in atherosclerotic arteries, the channeled balloon enabled simultaneous local drug delivery at low pressure during effective angioplasty, although particle size may play a role in successful intramural impregnation and retention.
Authors:
M K Hong; S C Wong; A Farb; M D Mehlman; R Virmani; J J Barry; M B Leon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Catheterization and cardiovascular diagnosis     Volume:  34     ISSN:  0098-6569     ISO Abbreviation:  Cathet Cardiovasc Diagn     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1996-01-17     Completed Date:  1996-01-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7508512     Medline TA:  Cathet Cardiovasc Diagn     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  263-70; discussion 271     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine (Cardiology Division), Washington Hospital Center, Washington, D.C., USA.
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Balloon / instrumentation*
Angioplasty, Transluminal, Percutaneous Coronary / instrumentation
Animals
Arteriosclerosis / drug therapy*,  pathology
Combined Modality Therapy
Coronary Artery Disease / drug therapy,  pathology
Drug Delivery Systems / instrumentation*
Endothelium, Vascular / drug effects,  pathology
Feasibility Studies
Humans
Microscopy, Fluorescence
Muscle, Smooth, Vascular / drug effects,  pathology
Particle Size
Rabbits
Thrombolytic Therapy / instrumentation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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