Document Detail

Localized cicatricial pemphigoid of the Brunsting-Perry type with transition into disseminated cicatricial pemphigoid. Report of a case proved by preembedding immunogold electron microscopy.
MedLine Citation:
PMID:  7741546     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In 1979, Provost described two patients with the clinical features of disseminated cicatricial pemphigoid for the first time. Until now, only four additional cases of disseminated cicatricial pemphigoid have been described. Existence of diagnosis of disseminated cicatricial pemphigoid has been discussed controversially because in four cases investigated by electron microscopy the blister formation was found below the lamina densa, which is indicative of an epidermolysis bullosa acquisita. OBSERVATION: A 78-year-old woman is presented with a generalized eruption of blisters leaving behind scars that developed after a 7-year-long history of mild circumscribed recurrent blisters and scarring eruptions that had been diagnosed previously as Brunsting-Perry type of cicatricial pemphigoid. Immunofluorescence antigen mapping disclosed the blister formation above the lamina densa. Electron and immunoelectron microscopy using a preembedding immunogold technique revealed blister formation and antibody binding within the lamina lucida, predominantly below the subbasal dense plate. CONCLUSIONS: The clinical features of disseminated blistering followed by scarring, the immunofluorescence antigen mapping, and the electron and immunoelectron microscopic findings in our case for the first time clearly prove the existence of a disseminated cicatricial pemphigoid.
G Kurzhals; W Stolz; W Maciejewski; S Karpati; M Meurer; R Breit
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  131     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-08     Completed Date:  1995-06-08     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  580-5     Citation Subset:  AIM; IM    
Department of Dermatology and Allergology, City Hospital of Munich-Schwabing, Germany.
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MeSH Terms
Basement Membrane / pathology
Blister / pathology
Cicatrix / pathology
Complement C3 / analysis
Disease Progression
Facial Dermatoses / pathology*,  physiopathology
Fluorescent Antibody Technique
Immunoglobulin G / analysis
Microscopy, Electron
Microscopy, Immunoelectron
Pemphigoid, Benign Mucous Membrane / pathology*,  physiopathology
Scalp Dermatoses / pathology*,  physiopathology
Tissue Embedding
Reg. No./Substance:
0/Complement C3; 0/Immunoglobulin G

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