| [Localized cerebral blood flow changes in response to ADL-related vitality in elderly patients with dementia using single photon emission computed tomography]. | |
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MedLine Citation:
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PMID: 19179793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To clarify the area in the brain related to responsible for vitality and volition. METHODS: We studied 123 outpatients (39 men, 84 women, 77.7+/-6.7 years old) who visited the Center for comprehensive care on memory disorders in Kyorin University Hospital. No patients were prescribed with anti-depressants, anti-anxiety agents, psychomimetics, acetylcholinesterase inhibitors, Chinese herbal medicines or cerebrovascular circulation modifying drugs. Patients with frontotemporal dementia or depression were excluded. ADL-related vitality and volition was measured by a vitality index. Cerebral brain blood flow was measured by single photon emission computed tomography (99mTc-ECD SPECT). Relative blood flow changes were calculated by Statistical Parametric Mapping (SPM). Absolute blood flow changes were calculated by a three-dimensional stereotaxic ROI template on anatomically standardised 99mTc-ECD SPECT (3D SRT). Statistically significant correlations between semi-quantitatively measured scores of vitality index and blood flow changes in SPM and 3D-SRT were tested and displayed on a brain map. RESULTS: Analysis of relative and absolute blood flow showed that the common responsible area in the brain related to vitality was the frontal lobe, fronto-cingulate gyrus, temporal lobe, basal ganglia (caudate nucleus) and thalamus. Blood flow changes in the orbital gyrus were strongly correlated with vitality index specially in the frontal lobe. CONCLUSION: ADL-related vitality is affected mainly by the blood flow in the frontal-subcortical circuit. However, deep white matter was also important to determine vitality and volition. |
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Authors:
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Kazuki Sonohara; Kenji Toba; Ryuhei Nakai; Yoshio Kobayashi; Yukiko Moriya; Hiroshi Hasegawa; Koiti Kozaki; Hiroshi Matsuda |
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Publication Detail:
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Type: English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics Volume: 45 ISSN: 0300-9173 ISO Abbreviation: Nihon Ronen Igakkai Zasshi Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2009-01-30 Completed Date: 2009-03-17 Revised Date: 2011-07-29 |
Medline Journal Info:
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Nlm Unique ID: 7507332 Medline TA: Nihon Ronen Igakkai Zasshi Country: Japan |
Other Details:
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Languages: jpn Pagination: 615-21 Citation Subset: IM |
Affiliation:
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Department of Geriatric Medicine, Kyorin University School of Medicine. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living* Aged Alzheimer Disease / physiopathology* Cerebrovascular Circulation / physiology* Female Humans Male Tomography, Emission-Computed, Single-Photon Volition* |
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