Document Detail

Localized {beta}-adrenergic receptor blockade does not affect sweating during exercise.
MedLine Citation:
PMID:  21325648     Owner:  NLM     Status:  Publisher    
The purpose of the current study was to determine the effect of a locally administered non-selective β-adrenergic antagonist on sweat gland function during exercise. Systemically administered propranolol has previously been reported to increase, decrease, or not alter sweat production during exercise. To eliminate the confounding systemic effects associated with orally administered propranolol we used iontophoresis to deliver it to the eccrine sweat glands within a localized area on one forearm prior to exercise. Subjects (n = 14) reported to the laboratory (23 ± 1ºC, 35 ± 3% rH) after having refrained from exercise for at least 12 hours. Propranolol (1% solution) was administered to a 5 cm(2) area of the flexor surface of one forearm via iontophoresis (1.5 mA) for five minutes. The opposing arm underwent iontophoresis with a saline solution. Each subject then exercised on a motor driven treadmill at 75% of their age-predicted maximal heart rate for 20 minutes during which time sweat rate was measured simultaneously in both forearms. Immediately following exercise the number of active sweat glands was measured by applying iodine impregnated paper to each forearm. The mean ± SD sweat rate for the control and propranolol-treated forearm was 0.62 ± 41 mg⋅cm(-2)⋅min(-1) and 0.60 ± 0.44 mg⋅cm(-2)⋅min(-1), respectively (P = 0.86). The mean ± SD density of active sweat glands for the control and propranolol-treated forearm was 130 ± 6 glands⋅cm(-2) and 134 ± 5 glands⋅cm(-2), respectively, (P = 0.33). End-exercise skin temperature was 32.9 ± 0.2 ºC and 33.1 ± 0.3 ºC for the control and propranolol-treated forearm, respectively (P = 0.51). The results of the current study show that when propranolol is administered locally, thus eliminating the potential confounding systemic effects of the drug, it does not directly affect sweating during the initial stages of high-intensity exercise in young, healthy subjects.
Michael J Buono; Brian Tabor; Ailish White
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-16
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1San Diego State University.
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