| 'Localized amyloidosis': 123I-labelled SAP component scintigraphy and labial salivary gland biopsy. | |
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MedLine Citation:
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PMID: 9093588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In apparently localized amyloidosis, there is no appropriate test to determine whether systemic deposits exist. We studied the value of serum amyloid P component (SAP) scintigraphy and labial salivary gland (LSG) biopsy on patients with apparently localized amyloidosis in 12 patients who had neither clinical nor biological evidence of systemic amyloidosis. All patients had an LSG biopsy and echocardiography. Iodine-123-labelled serum amyloid P component (123I-SAP) scintigraphy was performed in all patients. Whole-body scintigraphy was done, and tissue retention was evaluated at 24 h and 48 h. Of these 12 patients, three had amyloidosis in their LSG and had abnormal 123I-SAP scintigraphy; these three had a secondary clinical history of systemic amyloidosis. Three other patients had abnormal 123I-SAP scintigraphy without detectable systemic amyloid deposits, but one had a previous history of bilateral carpal tunnel syndrome treated with infiltration. 123I-SAP scintigraphy in association with LSG biopsy may be helpful in determining the localized or systemic character of amyloid disease. |
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Authors:
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L Maulin; E Hachulla; M Deveaux; A Janin; B Wechsler; P Godeau; H Rousset; J H Barrier; P Y Hatron; B Devulder; D Huglo; X Marchandise |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: QJM : monthly journal of the Association of Physicians Volume: 90 ISSN: 1460-2725 ISO Abbreviation: QJM Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-04-17 Completed Date: 1997-04-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9438285 Medline TA: QJM Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 45-50 Citation Subset: IM |
Affiliation:
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Service de Médecine Interne, CHRU, Lille, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amyloid / metabolism Amyloidosis / diagnosis*, pathology, radionuclide imaging Biopsy Female Humans Iodine Radioisotopes / diagnostic use Male Middle Aged Salivary Glands / metabolism, pathology, radionuclide imaging Serum Amyloid P-Component / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amyloid; 0/Iodine Radioisotopes; 0/Serum Amyloid P-Component |
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