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Localized Amyloidosis of the Genitourinary Tract: Report of 5 New Cases and Review of the Literature.
MedLine Citation:
PMID:  21512410     Owner:  NLM     Status:  Publisher    
Primary localized amyloidosis of the genitourinary tract is a rare entity characterized by small pseudotumors localized in the renal pelvis, ureters, or bladder. Amyloid fibrils are derived from immunoglobulin light chains, but no systemic plasma cell proliferation is detected. The clinical and radiologic features mimic urinary tract cancer, and local treatment is indicated. The prognosis is excellent in most cases, although disease recurrence is possible.We report 5 new cases of localized amyloidosis of the urinary tract, with lambda (4/5), or kappa (1/5) chain amyloid protein, involving the bladder (5/5), and the ureter and renal pelvis (1/5), with multiple, bilateral lesions in 1 case. The presenting complaint was painless hematuria in 4 cases. All cases were of primary (AL)-type amyloidosis. All patients underwent extensive investigation, and none presented any signs of generalized amyloidosis. A favorable outcome was observed in every case. We performed a comprehensive review of the literature, and summarize the data.
Matthieu Monge; Dominique Chauveau; Carole Cordonnier; Laure-Hélène Noël; Claire Presne; Raïfah Makdassi; Maïté Jauréguy; Caroline Lecaque; Marianne Renou; Jean-Pierre Grünfeld; Gabriel Choukroun
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-21
Journal Detail:
Title:  Medicine     Volume:  -     ISSN:  1536-5964     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985248R     Medline TA:  Medicine (Baltimore)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From Departments of Nephrology-Dialysis-Transplantation (MM, CP, RM, MJ, CL, MR, GC) and Pathology (CC), CHU Amiens, Amiens; Department of Nephrology (DC), Rangueil Hospital, Toulouse; Departments of Pathology(LHN) and Nephrology (JPG), Necker Hospital, Paris; and ERI-12, INSERM (MM, GC), Jules Verne University, Amiens, France.
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