| Localized Amyloidosis of the Genitourinary Tract: Report of 5 New Cases and Review of the Literature. | |
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MedLine Citation:
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PMID: 21512410 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Primary localized amyloidosis of the genitourinary tract is a rare entity characterized by small pseudotumors localized in the renal pelvis, ureters, or bladder. Amyloid fibrils are derived from immunoglobulin light chains, but no systemic plasma cell proliferation is detected. The clinical and radiologic features mimic urinary tract cancer, and local treatment is indicated. The prognosis is excellent in most cases, although disease recurrence is possible.We report 5 new cases of localized amyloidosis of the urinary tract, with lambda (4/5), or kappa (1/5) chain amyloid protein, involving the bladder (5/5), and the ureter and renal pelvis (1/5), with multiple, bilateral lesions in 1 case. The presenting complaint was painless hematuria in 4 cases. All cases were of primary (AL)-type amyloidosis. All patients underwent extensive investigation, and none presented any signs of generalized amyloidosis. A favorable outcome was observed in every case. We performed a comprehensive review of the literature, and summarize the data. |
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Authors:
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Matthieu Monge; Dominique Chauveau; Carole Cordonnier; Laure-Hélène Noël; Claire Presne; Raïfah Makdassi; Maïté Jauréguy; Caroline Lecaque; Marianne Renou; Jean-Pierre Grünfeld; Gabriel Choukroun |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-21 |
Journal Detail:
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Title: Medicine Volume: - ISSN: 1536-5964 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985248R Medline TA: Medicine (Baltimore) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From Departments of Nephrology-Dialysis-Transplantation (MM, CP, RM, MJ, CL, MR, GC) and Pathology (CC), CHU Amiens, Amiens; Department of Nephrology (DC), Rangueil Hospital, Toulouse; Departments of Pathology(LHN) and Nephrology (JPG), Necker Hospital, Paris; and ERI-12, INSERM (MM, GC), Jules Verne University, Amiens, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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