Document Detail

Localization of ventricular tachycardia exit site and subsequent contraction sequence and functional effects with bedside radionuclide angiography.
MedLine Citation:
PMID:  19356489     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In an effort to better understand the clinical effects of ventricular tachycardia (VT), we sought to characterize function and conduction during VT in patients. BACKGROUND: The image evaluation of VT has been limited by the lack of technical tools and its often-dramatic hemodynamic effect. Objective bedside imaging of VT-induced changes in contraction pattern, synchrony, and volumes has never been performed but could aid in the understanding of rhythm tolerance. METHODS: Equilibrium radionuclide angiography (ERNA) with phase analysis was performed during the course of 32 VT rhythms. Left ventricular ejection fraction, wall motion, synchrony, relative volumes, and exit sites were compared in 13 patients tolerant to VT (Group I) and 9 intolerant to VT (Group II). RESULTS: The ERNA VT exit site agreed with the results of electrocardiogram in 26 of 32 (81%) cases and with electrophysiologic study in 16 of 19 (84%) cases (both p < 0.05). A greater rate (157 vs. 130, p < 0.0001) accompanied VT intolerance, but the exit site in 4 patients with multiple VT patterns also appeared important to tolerance. Left ventricular ejection fraction, similar in both groups in sinus rhythm, decreased with VT in Groups I (28 to 19) and II (31 to 15), both p<0.03, with a greater relative decrease in LV ejection fraction, LV stroke volume (65% vs. 45%, p < 0.01), cardiac output (30% vs. 2%), and LV end-diastolic volume (36% vs. 27%, both p < 0.001), in Group II. The standard deviation of LV phase angle (Ø) was the only parameter which differed between Groups I and II (35 vs. 45, p < 0.01) in sinus rhythm. With VT, wall motion deteriorated generally, but with greater standard deviation LVØ, p < 0.05, and dyssynchrony in Group II. Ventricular tachycardia induced 14 functional aneurysms, often adjacent to VT exit sites. CONCLUSIONS: A challenging bedside imaging protocol evaluated VT-induced changes. We found that the use of ERNA demonstrated function, synchrony, and volume differences between tolerant and intolerant VT rhythms, delineated the contraction pattern, and localized exit sites.
Elias Botvinick; Jesse Davis; Michael Dae; John O'Connell; Norberto Schechtmann; Joseph Abbott; Fred Morady; Peter Lanzer; John Iskikian; Melvin Scheinman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JACC. Cardiovascular imaging     Volume:  1     ISSN:  1876-7591     ISO Abbreviation:  JACC Cardiovasc Imaging     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2009-04-09     Completed Date:  2009-04-23     Revised Date:  2009-05-21    
Medline Journal Info:
Nlm Unique ID:  101467978     Medline TA:  JACC Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-13     Citation Subset:  IM    
Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA.
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MeSH Terms
Electrophysiologic Techniques, Cardiac
Gated Blood-Pool Imaging / instrumentation*
Middle Aged
Myocardial Contraction*
Point-of-Care Systems*
Predictive Value of Tests
Stroke Volume*
Tachycardia, Ventricular / physiopathology,  radionuclide imaging*
Ventricular Function, Left*
Young Adult
Comment In:
JACC Cardiovasc Imaging. 2008 Sep;1(5):614-6   [PMID:  19356490 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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