Document Detail

Localization and ultrastructure of the Kupffer cells in orthotopically transplanted liver grafts in the rat.
MedLine Citation:
PMID:  1786057     Owner:  NLM     Status:  MEDLINE    
Kupffer cells play an important role in the acceptance or rejection of liver grafts. We examined the ultrastructure of the Kupffer cells in transplanted rat livers, from an early to a late stage where the graft is accepted, using a DA-to-PVG combination. Two days after surgery, endocytic activity of the Kupffer cells had increased, as evidenced by worm-like structures and many endocytic vacuoles. There was often close apposition to the monocytes or lymphocytes. By day 4, infiltration of mononuclear cells into the sinusoids was readily noticeable. By day 7, several Kupffer cells had migrated into the space of Disse through the openings in endothelial linings. The number of Kupffer cells reached a maximum at 14 days. They were located mostly outside the sinusoid, adhering to the hepatocytes. At this point in time, however, the Kupffer cells contained few endocytic vacuoles and phagolysosomes, in contrast to those at 2 days. The number and location of Kupffer cells became almost normal at 2 months. The present results indicate that Kupffer cells are highly activated before mononuclear cell infiltration becomes manifest in the sinusoid, and that when a rejecting reaction reaches a peak, they are usually located extrasinusoidally and show a morphologically immature profile.
K Kaneda; K Teramoto; H Yamamoto; K Wake; N Kamada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplant international : official journal of the European Society for Organ Transplantation     Volume:  4     ISSN:  0934-0874     ISO Abbreviation:  Transpl. Int.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-03-23     Completed Date:  1992-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908516     Medline TA:  Transpl Int     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  205-9     Citation Subset:  IM    
Department of Anatomy, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Kupffer Cells / ultrastructure*
Leukocytes, Mononuclear / ultrastructure
Liver / ultrastructure
Liver Transplantation / pathology*
Rats, Inbred Strains
Transplantation, Homologous

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