Document Detail


Localization of sulfatides in the epithelial lining of gastric mucosa: studies with a monoclonal antibody to sulfatides.
MedLine Citation:
PMID:  8774999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A specific monoclonal antibody against sulfatides was used to examine the cellular localization of sulfatides, the most predominant acidic glycosphingolipids in both rabbit and human gastric mucosa. The monoclonal antibody selectively recognized sulfatides among the acidic glycolipids extracted from rabbit gastric mucosa. Immunofluorescence staining revealed that specific staining was localized in the epithelial cells of the stomach. Both epithelial and glandular cells were stained in the fundic mucosa. In human stomach, the staining pattern was essentially identical to that in rabbit stomach. The specific localization of sulfatides in the epithelial lining supports our hypothesis that they may be a component of mucosal defensive substances and an adhesion receptor for Helicobacter pylori.
Authors:
K Sugano; T Tai; I Kawashima; M Kotani; H Natomi; S Kamisago; Y Fukushima; Y Yazaki; M Iwamori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  21 Suppl 1     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1995  
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S98-103     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal
Chromatography, Thin Layer
Epithelium / metabolism
Fluorescent Antibody Technique, Indirect
Gastric Mucosa / cytology,  metabolism*
Glycosphingolipids / metabolism*
Immunohistochemistry
Rabbits
Sulfoglycosphingolipids / metabolism*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Glycosphingolipids; 0/Sulfoglycosphingolipids

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