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LOCALIZATION OF RIBONUCLEIC ACID IN THE CYTOPLASM OF LIVER CELLS.
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MedLine Citation:
PMID:  19871549     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The attempt has been made to determine the character of the basophile material that occurs normally in the cytoplasm of liver cells and accumulates in association with the hyperplasia of liver cells and of newly formed bile ducts when the azo dye butter yellow is administered to white rats. This substance in the normal liver cells, in the parenchymatous foci of basophile hyperplasia that are precursors of hepatomas, and in the hyperplastic basophile ducts that precede the cholangiomas produced by butter yellow has the characteristics of ribonucleic acid. It absorbs ultraviolet radiation of wave length 2537 A. It does not, like desoxyribonucleic acid, give the Feulgen reaction. It is removed from the cytoplasm by ribonuclease, and precipitation with lanthanum acetate protects it against the enzyme.
Authors:
E L Opie; G I Lavin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  84     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1946 Jun 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-06-22     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-12     Citation Subset:  -    
Affiliation:
Laboratories of The Rockefeller Institute for Medical Research.
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Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1946, by The Rockefeller Institute for Medical Research New York
Received Day: 20 Month: 2 Year: 1946
Print publication date: Day: 30 Month: 6 Year: 1946
Volume: 84 Issue: 1
First Page: 107 Last Page: 112
ID: 2135636
PubMed Id: 19871549

LOCALIZATION OF RIBONUCLEIC ACID IN THE CYTOPLASM OF LIVER CELLS
Eugene L. Opie
George I. Lavin
From the Laboratories of The Rockefeller Institute for Medical Research


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