| Localization of renal tubular uric acid transport defect in gouty chickens. | |
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MedLine Citation:
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PMID: 1211475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chickens genetically selected for high incidence of articular gout and hyperuricemia were used to determine the site of defective uric acid (UA) transport in gout. The Sperber technique was used to compare the tubular secretion of preformed UA with the tubular secretion of UA formed within the tubular cells in gouty and nongouty chickens of the same strain. In gouty chickens, the tubular excretion ratio of preformed [14C]UA was 36% of the value obtained in nongouty chickens of the same strain, whereas the tubular excretion ratios of [14C]UA formed within the tubular cells from [14C]guanine were equal in the two types of chickens. This suggests that a UA transport is located at the peritubular membrane and that this mechanism is defective in gouty chickens. In addition, the transport of p-aminohippurate (PAH) was normal in gouty chickens, which suggests that the transport mechanism for UA is distinct from that for PAH. |
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Authors:
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M J Zmuda; A J Quebbemann |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 229 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1975 Sep |
Date Detail:
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Created Date: 1976-03-11 Completed Date: 1976-03-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 820-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminohippuric Acids
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administration & dosage,
metabolism Animals Biological Transport Chickens Gout / blood, metabolism* Guanine / metabolism Kidney Tubules / metabolism* Uric Acid / administration & dosage, blood, metabolism* Xanthines / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Aminohippuric Acids; 0/Xanthines; 69-93-2/Uric Acid; 73-40-5/Guanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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