Document Detail

Localization of renal kallikrein-kinin system components in the kidney.
MedLine Citation:
PMID:  3012161     Owner:  NLM     Status:  MEDLINE    
In a study using a stop-flow technique in dog kidney, the existence of kallikrein and kinin was recognized in distal tubules. The presence of kininase I was seen in both distal and proximal tubules, and also partly in the distal tubules. The presence of kininase II in the distal tubules was again confirmed by pretreatment with SQ14225. No evidence of kinin formation, however, was obtained in the proximal nephrons in stop-flow method. From these results, it was suggested that kininase I and II localized in proximal tubules may destroy the kinin filtered from glomeruli at the proximal level, while kallikrein and kininogen and also kininase I and II in the distal tubules may regulate the activity of the renal kallikrein-kinin system in the distal nephrons.
Y Yamaguchi; K Shimamoto; N Ura; T Nishimiya; M Nakagawa; A Masuda; T Ando; O Iimura
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of medicine     Volume:  25     ISSN:  0021-5120     ISO Abbreviation:  Jpn. J. Med.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0247713     Medline TA:  Jpn J Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
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MeSH Terms
Kallikreins / metabolism*
Kidney / metabolism*
Kidney Tubules, Distal / metabolism
Kidney Tubules, Proximal / metabolism
Kinins / metabolism*
Lysine Carboxypeptidase / metabolism
Peptidyl-Dipeptidase A / metabolism
Tissue Distribution
Reg. No./Substance:
0/Kinins; EC A; EC Carboxypeptidase; EC 3.4.21.-/Kallikreins

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