Document Detail


Localization of relaxin in endometrial gland cells of pregnant, lactating, and ovariectomized hormone-treated guinea pigs.
MedLine Citation:
PMID:  7102575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uteri taken from guinea pigs in different stages of pregnancy and during lactation, as well as animals that had been ovariectomized and treated with hormones, were examined for relaxin with the peroxidase-antiperoxidase (PAP) technique employing an antiserum produced against porcine relaxin. While relaxin was not detected in uteri of day 15 pregnant animals, small amounts were noted in a few endometrial glands in day 30 pregnant animals. Uteri from day 45, day 60, and late-pregnant animals exhibited heavy amounts of relaxin; however, endometrial gland cells from lactating animals contained very little or no relaxin. Injections of estrogen and progesterone that brought a relaxation of the pelvic ligaments in ovariectomized guinea pigs also induced an accumulation of relaxin in the endometrial glands. Relaxin was not detected in nonendometrial portions of the uterus, endometrial stromal components, luminal surface epithelium, or uterine cervical glands. Extracts prepared from uteri of day 45, day 60, and late-pregnant animals showed positive responses for relaxin in the mouse uterus bioassay.
Authors:
R J Pardo; L H Larkin
Related Documents :
7230125 - Effect of oestrogen on pregnancy of guinea-pigs.
24183755 - Effect of lipid composition of cationic suv liposomes on materno-fetal transfer of warf...
23433535 - Increased vwf antigen levels and decreased adamts13 activity in preeclampsia.
7250405 - The function of the corpus luteum of pregnancy in ovulatory dysfunction and luteal phas...
21716935 - In vitro fertilization/intracytoplasmic sperm injection for male infertility.
3109245 - Management of term breech presentation.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of anatomy     Volume:  164     ISSN:  0002-9106     ISO Abbreviation:  Am. J. Anat.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-09-17     Completed Date:  1982-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376312     Medline TA:  Am J Anat     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-90     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Castration
Endometrium / analysis*,  anatomy & histology,  cytology
Estradiol / pharmacology*
Female
Guinea Pigs
Lactation*
Ovary / physiology*
Pregnancy
Progesterone / pharmacology*
Relaxin / isolation & purification*
Grant Support
ID/Acronym/Agency:
HD-08552/HD/NICHD NIH HHS; HD-15576/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone; 9002-69-1/Relaxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Anatomy and innervation patterns of cat lateral gastrocnemius and plantaris muscles.
Next Document:  Reproductive tract abnormalities in rats treated neonatally with DES.