| Localization of prolyl hydroxylase by the immunoperoxidase method in cardiovascular tissues of hypertensive rats. | |
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MedLine Citation:
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PMID: 215794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An immunohistochemical method and light microscopy were utilized to determine localization of prolyl hydroxylase in the cardiovascular tissues of hypertensive rats. The blood vessels and renal glomerulus from these animals demonstrated an enhanced immunoreaction for prolyl hydroxylase. As the most prominent staining was observed in medial smooth muscle cells of blood vessels, these are probably the major collagen-producing cells in arteriosclerotic lesions induced by hypertension. In the glomerulus, endothelial cells and probably mesangial cells are mainly responsible for the collagen formation. An intense immunoreaction was also found in the fibroblasts which proliferated in the area of myocardial fibrosis in hypertensive rats, while there was no specific staining in myocardial cells in either hypertensive or normotensive rats. |
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Authors:
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A Ooshima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 42 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1978 Aug |
Date Detail:
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Created Date: 1979-03-24 Completed Date: 1979-03-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 971-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular System / enzymology*, pathology Histocytochemistry Hypertension / enzymology*, pathology Immunoenzyme Techniques* Male Procollagen-Proline Dioxygenase / metabolism* Rats |
| Chemical | |
Reg. No./Substance:
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EC 1.14.11.2/Procollagen-Proline Dioxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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