| Localization of preproenkephalin A mRNA in the neonatal rat retina. | |
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MedLine Citation:
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PMID: 1786557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An opioid growth factor, [Met5]-enkephalin, is known to regulate developmental events in the neonatal rat retina. This growth factor interacts with the zeta (zeta) opioid receptor to modulate retinal ontogeny. Both peptide and receptor are present in developing retina, but not in adult retina. We have used in situ hybridization histochemistry to identify and localize preproenkephalin A mRNA in the neonatal rat retina. Preproenkephalin mRNA was localized to the ganglion cell layer, with some radiolabeling found in the neuroblast layer. This result indicates that 1) the mRNA to preproenkephalin A is present during the critical stage of development in the neonatal retina that coincides with the presence of the growth-regulating peptide, [Met5]-enkephalin, and 2) that the source of the opioid growth factor controlling the production of retinal cells appears to be autocrine (i.e., retinal neuroblasts) and paracrine (i.e., ganglion cells) in nature. |
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Authors:
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T Isayama; I S Zagon |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research bulletin Volume: 27 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-03-24 Completed Date: 1992-03-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 805-8 Citation Subset: IM |
Affiliation:
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Department of Neuroscience and Anatomy, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Autoradiography Enkephalins / genetics* Female Histocytochemistry Male Nucleic Acid Hybridization Oligonucleotide Probes Protein Precursors / genetics* RNA, Messenger / metabolism* Rats Rats, Inbred Strains Retina / metabolism* Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
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NS-20500/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enkephalins; 0/Oligonucleotide Probes; 0/Protein Precursors; 0/RNA, Messenger; 93443-35-7/preproenkephalin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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