| Localization of oestradiol in the rat nasal mucosa. | |
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MedLine Citation:
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PMID: 4083037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolism of 4-14C-oestradiol in the rodent respiratory tract has been investigated in vitro. Using thin-layer radiochromatography, at least 3 and 2 metabolites were found at incubation with slices from the rat olfactory mucosa and lung, respectively. Autoradiography of the nasal region of rats injected intravenously with 4-14C-oestradiol showed a high level of radioactivity in the mucosa covering the respiratory region, and in the subepithelial parts of the olfactory mucosa. Autoradiography of rat and mouse lung slices incubated with 4-14C-oestradiol showed that a selective localization of radioactivity occurred in the bronchial mucosa. The radioactivity in the mucosa of the respiratory tract was reversibly bound and could be extracted with organic solvents. |
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Authors:
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E B Brittebo |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta pharmacologica et toxicologica Volume: 57 ISSN: 0001-6683 ISO Abbreviation: Acta Pharmacol Toxicol (Copenh) Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1986-02-14 Completed Date: 1986-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370572 Medline TA: Acta Pharmacol Toxicol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 285-90 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Estradiol / metabolism* Female Lung / metabolism Metyrapone / metabolism Mice Mice, Inbred C57BL Nasal Mucosa / metabolism* Rats Rats, Inbred Strains Species Specificity |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 54-36-4/Metyrapone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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