Document Detail

Localization of oestradiol in the rat nasal mucosa.
MedLine Citation:
PMID:  4083037     Owner:  NLM     Status:  MEDLINE    
The metabolism of 4-14C-oestradiol in the rodent respiratory tract has been investigated in vitro. Using thin-layer radiochromatography, at least 3 and 2 metabolites were found at incubation with slices from the rat olfactory mucosa and lung, respectively. Autoradiography of the nasal region of rats injected intravenously with 4-14C-oestradiol showed a high level of radioactivity in the mucosa covering the respiratory region, and in the subepithelial parts of the olfactory mucosa. Autoradiography of rat and mouse lung slices incubated with 4-14C-oestradiol showed that a selective localization of radioactivity occurred in the bronchial mucosa. The radioactivity in the mucosa of the respiratory tract was reversibly bound and could be extracted with organic solvents.
E B Brittebo
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmacologica et toxicologica     Volume:  57     ISSN:  0001-6683     ISO Abbreviation:  Acta Pharmacol Toxicol (Copenh)     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-02-14     Completed Date:  1986-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370572     Medline TA:  Acta Pharmacol Toxicol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  IM    
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MeSH Terms
Estradiol / metabolism*
Lung / metabolism
Metyrapone / metabolism
Mice, Inbred C57BL
Nasal Mucosa / metabolism*
Rats, Inbred Strains
Species Specificity
Reg. No./Substance:
50-28-2/Estradiol; 54-36-4/Metyrapone

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