Document Detail

Localization of myosin-Va in subpopulations of cells in rat endocrine organs.
MedLine Citation:
PMID:  18568366     Owner:  NLM     Status:  MEDLINE    
Myosin-Va is a Ca(2+)/calmodulin-regulated unconventional myosin involved in the transport of vesicles, membranous organelles, and macromolecular complexes composed of proteins and mRNA. The cellular localization of myosin-Va has been described in great detail in several vertebrate cell types, including neurons, melanocytes, lymphocytes, auditory tissues, and a number of cultured cells. Here, we provide an immunohistochemical view of the tissue distribution of myosin-Va in the major endocrine organs. Myosin-Va is highly expressed in the pineal and pituitary glands and in specific cell populations of other endocrine glands, especially the parafollicular cells of the thyroid, the principal cells of the parathyroid, the islets of Langerhans of the pancreas, the chromaffin cells of the adrenal medulla, and a subpopulation of interstitial testicular cells. Weak to moderate staining has been detected in steroidogenic cells of the adrenal cortex, ovary, and Leydig cells. Myosin-Va has also been localized to non-endocrine cells, such as the germ cells of the seminiferous epithelium and maturing oocytes and in the intercalated ducts of the exocrine pancreas. These data provide the first systematic description of myosin-Va localization in the major endocrine organs of rat.
Foued S Espindola; Silmara R Banzi; Luciana K Calabria; Rodrigo J Custódio; Ricardo A Oliveira; Leandro D Procópio; Andreia B P Lima; Jair P Cunha-Junior; Milton V Coelho; Iêda M L Guedes; Cláudia H Pellizzon; Roy E Larson; Enilza M Espreafico
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-21
Journal Detail:
Title:  Cell and tissue research     Volume:  333     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  263-79     Citation Subset:  IM    
Instituto de Genética e Bioquímica, Laboratório de Bioquímica e Biologia Molecular, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.
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MeSH Terms
Adrenal Glands / cytology,  metabolism
Endocrine Glands* / cytology,  metabolism
Islets of Langerhans / cytology,  metabolism
Myosin Heavy Chains / metabolism*
Myosin Type V / metabolism*
Parathyroid Glands / cytology,  metabolism
Pineal Gland / cytology,  metabolism
Pituitary Gland / cytology,  metabolism
Thyroid Gland / cytology,  metabolism
Tissue Distribution
Reg. No./Substance:
0/Myo5a protein, rat; 0/Myosin Heavy Chains; EC 3.6.1.-/Myosin Type V

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