| Localization of magnetic pills. | |
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MedLine Citation:
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PMID: 21257903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous therapeutics demonstrate optimal absorption or activity at specific sites in the gastrointestinal (GI) tract. Yet, safe, effective pill retention within a desired region of the GI remains an elusive goal. We report a safe, effective method for localizing magnetic pills. To ensure safety and efficacy, we monitor and regulate attractive forces between a magnetic pill and an external magnet, while visualizing internal dose motion in real time using biplanar videofluoroscopy. Real-time monitoring yields direct visual confirmation of localization completely noninvasively, providing a platform for investigating the therapeutic benefits imparted by localized oral delivery of new and existing drugs. Additionally, we report the in vitro measurements and calculations that enabled prediction of successful magnetic localization in the rat small intestines for 12 h. The designed system for predicting and achieving successful magnetic localization can readily be applied to any area of the GI tract within any species, including humans. The described system represents a significant step forward in the ability to localize magnetic pills safely and effectively anywhere within the GI tract. What our magnetic pill localization strategy adds to the state of the art, if used as an oral drug delivery system, is the ability to monitor the force exerted by the pill on the tissue and to locate the magnetic pill within the test subject all in real time. This advance ensures both safety and efficacy of magnetic localization during the potential oral administration of any magnetic pill-based delivery system. |
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Authors:
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Bryan Laulicht; Nicholas J Gidmark; Anubhav Tripathi; Edith Mathiowitz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-01-21 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 108 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-09 Completed Date: 2011-03-30 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 2252-7 Citation Subset: IM |
Affiliation:
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Department of Molecular Pharmacology, Brown University, Providence, RI 02912, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fluoroscopy Humans Intestinal Absorption / physiology* Intestine, Small / physiology*, radiography* Magnetics* Male Pharmacokinetics* Rats Rats, Sprague-Dawley |
| Comments/Corrections | |
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