Document Detail

Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization.
MedLine Citation:
PMID:  9125186     Owner:  NLM     Status:  MEDLINE    
Expression of leptin receptor splice variants, including the long form variant (Ob-Rb), has been examined in murine peripheral tissues. RT-PCR indicates that the leptin receptor, Ob-R, and in particular the Ob-Ra splice variant are expressed in a wide range of tissues. Expression of the Ob-R receptor was localized by in situ hybridization to specific sites in the spleen, testes, kidney, liver, lung, and adrenal. However, the long form leptin receptor, Ob-Rb, was only expressed at significant levels in the medulla of the adrenal and the inner zone of the medulla of the kidney. The specific sites of expression of different splice variants within peripheral tissues has important implications with regard to the function of leptin.
N Hoggard; J G Mercer; D V Rayner; K Moar; P Trayhurn; L M Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  232     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-22     Completed Date:  1997-04-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-7     Citation Subset:  IM    
Molecular Physiology Group, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/U49106;  U49107
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MeSH Terms
Carrier Proteins / genetics*
In Situ Hybridization
Molecular Sequence Data
Organ Specificity / genetics*
Polymerase Chain Reaction
RNA Splicing*
RNA, Messenger / metabolism*
RNA-Directed DNA Polymerase
Receptors, Cell Surface*
Receptors, Cytokine / genetics*
Receptors, Leptin
Reg. No./Substance:
0/Carrier Proteins; 0/RNA, Messenger; 0/Receptors, Cell Surface; 0/Receptors, Cytokine; 0/Receptors, Leptin; 0/leptin receptor, mouse; EC DNA Polymerase

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