| Localization of gastrinomas by selective intra-arterial calcium injection in patients on proton pump inhibitor or H2 receptor antagonist therapy. | |
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MedLine Citation:
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PMID: 15756095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preoperative localization is important for the successful treatment of gastrinomas. The aim of this study was to investigate whether selective intra-arterial calcium injection and hepatic venous sampling was able to localize gastrinomas in four patients who remained on proton pump inhibitor or H2 antagonist therapy. Calcium gluconate was injected directly into the arteries supplying the pancreas and liver after standard selective angiography. Gastrin levels were then measured in samples taken from the right hepatic vein. Calcium gluconate produced a diagnostic rise (at least 2-fold) in serum gastrin and unequivocally localized the tumour to a specific vascular territory in each case. One patient did not undergo surgery. In the remaining three patients, surgery confirmed the position and histology of the tumour. This study shows that in four patients with a confirmed gastrinoma we were able to localize the gastrinoma by selective intra-arterial calcium injection and hepatic venous sampling, whilst the patients remained on proton pump inhibitor or H2 antagonist therapy, thereby reducing their risk of gastrointestinal perforation. |
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Authors:
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Waljit S Dhillo; Channa N L Jayasena; James E Jackson; John A Lynn; Stephen R Bloom; Karim Meeran; Jeannie F Todd |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: 17 ISSN: 0954-691X ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-09 Completed Date: 2005-05-31 Revised Date: 2009-10-16 |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 429-33 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Specimen Collection Calcium Gluconate / diagnostic use* Female Gastrinoma / diagnosis*, drug therapy Hepatic Veins Histamine H2 Antagonists / therapeutic use* Humans Injections, Intra-Arterial Intestinal Perforation / prevention & control Liver / blood supply Male Middle Aged Omeprazole / therapeutic use Pancreas / blood supply Pancreatic Neoplasms / diagnosis*, drug therapy Proton Pumps / antagonists & inhibitors* Ranitidine / therapeutic use Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 0/Proton Pumps; 299-28-5/Calcium Gluconate; 66357-35-5/Ranitidine; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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