Document Detail


Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization.
MedLine Citation:
PMID:  3337914     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In situ hybridization was used to localize the cells that produce erythropoietin (EP) in anemic murine kidneys. Kidneys from anemic and nonanemic mice were fixed and processed for paraffin embedding. Sections were hybridized with a 35S-labeled RNA probe complementary to mRNA coding for EP. An uncommon, but specific type of cell was intensely labeled in the cortices of anemic kidneys. The labeled cells were clearly nonglomerular and nontubular. Their location outside of the tubular basement membrane was consistent with that of a subset of interstitial cells or capillary endothelial cells.
Authors:
S T Koury; M C Bondurant; M J Koury
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  71     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-04     Completed Date:  1988-03-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  524-7     Citation Subset:  AIM; IM    
Affiliation:
Vanderbilt University Medical Center, Nashville, TN.
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MeSH Terms
Descriptor/Qualifier:
Anemia / physiopathology
Animals
Erythropoietin / biosynthesis*
Kidney / cytology*,  metabolism
Mice
Nucleic Acid Hybridization
Grant Support
ID/Acronym/Agency:
DK 31513/DK/NIDDK NIH HHS; F32 DK08027/DK/NIDDK NIH HHS; RR-05424/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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