Document Detail


Localization of eosinophil granule major basic protein in chronic urticaria.
MedLine Citation:
PMID:  6345685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of the eosinophil in the pathogenesis of cutaneous diseases is not known. The eosinophil granule major basic protein (MBP), constituting the core and accounting for greater than 50% of the eosinophil granule, is toxic to helminths and mammalian cells. To determine whether eosinophil degranulation occurs in lesions of chronic urticaria, we performed an indirect immunofluorescence assay on sections of formalin-fixed, paraffin-embedded tissue, utilizing affinity chromatography-purified antibody to MBP. Twelve of 28 biopsies showed evidence of degranulation as judged by the deposition of MBP outside the eosinophil. The positive staining was of 3 types: (1) small blood vessel walls (5 patients), (2) dispersion of granular material (9 patients), and (3) focal or diffuse immunofluorescence of connective tissue fibers (11 patients). These results suggest a possible role for the cytotoxic molecule MBP in the evolution of lesions of chronic urticaria.
Authors:
M S Peters; A L Schroeter; G M Kephart; G J Gleich
Related Documents :
7247195 - Delayed skin reactivity of patients with herpetic stromal keratitis.
12900605 - Abdominal wall partitioning (the accordion effect) for reconstruction of major defects:...
2309105 - Reduced strength of skin in ehlers danlos syndrome, type iii.
10467275 - Multicentric warfarin-induced skin necrosis complicating heparin-induced thrombocytopenia.
24481095 - Epicardial fat thickness in patients with psoriasis vulgaris.
2087295 - Purtscher's-like retinopathy after childbirth.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  81     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Proteins / metabolism*
Child
Child, Preschool
Chronic Disease
Cytoplasmic Granules / metabolism*
Eosinophil Granule Proteins
Eosinophils / metabolism*,  ultrastructure
Female
Fluorescent Antibody Technique
Histocytochemistry
Humans
Male
Middle Aged
Ribonucleases*
Skin / metabolism
Urticaria / metabolism*
Grant Support
ID/Acronym/Agency:
AI-15231/AI/NIAID NIH HHS; AI-9728/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Eosinophil Granule Proteins; EC 3.1.-/Ribonucleases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Influence of Langerhans cells on the survival of H-Y incompatible skin grafts in rats.
Next Document:  Involucrin and other markers of keratinocyte terminal differentiation.