| Localization of eosinophil granule major basic protein in chronic urticaria. | |
| | |
MedLine Citation:
|
PMID: 6345685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of the eosinophil in the pathogenesis of cutaneous diseases is not known. The eosinophil granule major basic protein (MBP), constituting the core and accounting for greater than 50% of the eosinophil granule, is toxic to helminths and mammalian cells. To determine whether eosinophil degranulation occurs in lesions of chronic urticaria, we performed an indirect immunofluorescence assay on sections of formalin-fixed, paraffin-embedded tissue, utilizing affinity chromatography-purified antibody to MBP. Twelve of 28 biopsies showed evidence of degranulation as judged by the deposition of MBP outside the eosinophil. The positive staining was of 3 types: (1) small blood vessel walls (5 patients), (2) dispersion of granular material (9 patients), and (3) focal or diffuse immunofluorescence of connective tissue fibers (11 patients). These results suggest a possible role for the cytotoxic molecule MBP in the evolution of lesions of chronic urticaria. |
| | |
Authors:
|
M S Peters; A L Schroeter; G M Kephart; G J Gleich |
Related Documents
:
|
7247195 - Delayed skin reactivity of patients with herpetic stromal keratitis. 12900605 - Abdominal wall partitioning (the accordion effect) for reconstruction of major defects:... 2309105 - Reduced strength of skin in ehlers danlos syndrome, type iii. 10467275 - Multicentric warfarin-induced skin necrosis complicating heparin-induced thrombocytopenia. 2087295 - Purtscher's-like retinopathy after childbirth. 986025 - Normocalcemic tetany. a problem of erethism. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of investigative dermatology Volume: 81 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 1983 Jul |
Date Detail:
|
Created Date: 1983-08-11 Completed Date: 1983-08-11 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 39-43 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Blood Proteins / metabolism* Child Child, Preschool Chronic Disease Cytoplasmic Granules / metabolism* Eosinophil Granule Proteins Eosinophils / metabolism*, ultrastructure Female Fluorescent Antibody Technique Histocytochemistry Humans Male Middle Aged Ribonucleases* Skin / metabolism Urticaria / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
AI-15231/AI/NIAID NIH HHS; AI-9728/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Proteins; 0/Eosinophil Granule Proteins; EC 3.1.-/Ribonucleases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of Langerhans cells on the survival of H-Y incompatible skin grafts in rats.
Next Document: Involucrin and other markers of keratinocyte terminal differentiation.