Document Detail


Localization of endothelin immunoreactivity and demonstration of constrictory endothelin-A receptors in human coronary arteries and veins.
MedLine Citation:
PMID:  7516007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Strong immunoreactivity for endothelins (ETs) was observed in the endothelium of both human epicardial coronary arteries and veins. The contractile responses to ET-1, ET-2, and ET-3 were investigated in isolated circular human coronary vessel segments. ET-1, ET-2, and ET-3 induced significantly higher maximum contraction (measured in percentage of contraction induced by 60 mM potassium) and more potent responses in veins as compared with arteries. ET-1 as compared with ET-2 induced equal maximum contraction and equipotent responses both when tested in arteries and veins, whereas ET-3 induced lower maximum contraction and less potent responses in both vessel types. FR 139317, a selective ETA receptor antagonist, significantly decreased the potency of ET-1 and ET-2 responses in both human coronary arteries and veins, but the maximum effect obtained did not change significantly. The existence of ET immunoreactivity (IR) in endothelial cells from both human coronary arteries and veins indicates that ETs may be released endogenously. The effect of the selective ETA receptor antagonist FR 139317 indicates that the contraction induced by ET-1 and ET-2 in both arteries and veins is mediated by ETA receptors.
Authors:
O Saetrum Opgaard; M Adner; S Gulbenkian; L Edvinsson
Related Documents :
8458587 - Decreased endothelium-dependent vascular relaxation following subtotal coronary artery ...
8931767 - Pharmacological evidence that different alpha 1 adrenoceptor subtypes mediate contracti...
8564247 - Effects of u46619 on contractions to 5-ht, sumatriptan and methysergide in canine coron...
8181037 - Endothelial function of human gastroepiploic artery in comparison with saphenous vein.
22394037 - Low density lipoprotein size in relation to carotid intima-media thickness in coronary ...
3156887 - Reversible optic neuropathy due to carotid-cavernous fistula.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  23     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-07-08     Completed Date:  1994-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  576-83     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University Hospital of Lund, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Arteries / chemistry
Azepines / pharmacology
Coronary Vessels / chemistry*,  physiology
Endothelins / immunology*,  metabolism
Humans
Immunohistochemistry
Indoles / pharmacology
Receptors, Endothelin / analysis*,  antagonists & inhibitors
Vasoconstriction / physiology
Veins / chemistry
Chemical
Reg. No./Substance:
0/Azepines; 0/Endothelins; 0/Indoles; 0/Receptors, Endothelin; 142375-60-8/FR 139317

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chronotropic cardiac effects of falipamil in conscious dogs: interactions with the autonomic nervous...
Next Document:  Efficacy of angiotensin-converting enzyme inhibition and AT1 receptor blockade on cardiac pump perfo...