Document Detail

Localization of endothelin immunoreactivity and demonstration of constrictory endothelin-A receptors in human coronary arteries and veins.
MedLine Citation:
PMID:  7516007     Owner:  NLM     Status:  MEDLINE    
Strong immunoreactivity for endothelins (ETs) was observed in the endothelium of both human epicardial coronary arteries and veins. The contractile responses to ET-1, ET-2, and ET-3 were investigated in isolated circular human coronary vessel segments. ET-1, ET-2, and ET-3 induced significantly higher maximum contraction (measured in percentage of contraction induced by 60 mM potassium) and more potent responses in veins as compared with arteries. ET-1 as compared with ET-2 induced equal maximum contraction and equipotent responses both when tested in arteries and veins, whereas ET-3 induced lower maximum contraction and less potent responses in both vessel types. FR 139317, a selective ETA receptor antagonist, significantly decreased the potency of ET-1 and ET-2 responses in both human coronary arteries and veins, but the maximum effect obtained did not change significantly. The existence of ET immunoreactivity (IR) in endothelial cells from both human coronary arteries and veins indicates that ETs may be released endogenously. The effect of the selective ETA receptor antagonist FR 139317 indicates that the contraction induced by ET-1 and ET-2 in both arteries and veins is mediated by ETA receptors.
O Saetrum Opgaard; M Adner; S Gulbenkian; L Edvinsson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  23     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-07-08     Completed Date:  1994-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  576-83     Citation Subset:  IM    
Department of Internal Medicine, University Hospital of Lund, Sweden.
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MeSH Terms
Arteries / chemistry
Azepines / pharmacology
Coronary Vessels / chemistry*,  physiology
Endothelins / immunology*,  metabolism
Indoles / pharmacology
Receptors, Endothelin / analysis*,  antagonists & inhibitors
Vasoconstriction / physiology
Veins / chemistry
Reg. No./Substance:
0/Azepines; 0/Endothelins; 0/Indoles; 0/Receptors, Endothelin; 142375-60-8/FR 139317

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