| Localization of endothelin immunoreactivity and demonstration of constrictory endothelin-A receptors in human coronary arteries and veins. | |
| | |
MedLine Citation:
|
PMID: 7516007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Strong immunoreactivity for endothelins (ETs) was observed in the endothelium of both human epicardial coronary arteries and veins. The contractile responses to ET-1, ET-2, and ET-3 were investigated in isolated circular human coronary vessel segments. ET-1, ET-2, and ET-3 induced significantly higher maximum contraction (measured in percentage of contraction induced by 60 mM potassium) and more potent responses in veins as compared with arteries. ET-1 as compared with ET-2 induced equal maximum contraction and equipotent responses both when tested in arteries and veins, whereas ET-3 induced lower maximum contraction and less potent responses in both vessel types. FR 139317, a selective ETA receptor antagonist, significantly decreased the potency of ET-1 and ET-2 responses in both human coronary arteries and veins, but the maximum effect obtained did not change significantly. The existence of ET immunoreactivity (IR) in endothelial cells from both human coronary arteries and veins indicates that ETs may be released endogenously. The effect of the selective ETA receptor antagonist FR 139317 indicates that the contraction induced by ET-1 and ET-2 in both arteries and veins is mediated by ETA receptors. |
| | |
Authors:
|
O Saetrum Opgaard; M Adner; S Gulbenkian; L Edvinsson |
Related Documents
:
|
8458587 - Decreased endothelium-dependent vascular relaxation following subtotal coronary artery ... 8931767 - Pharmacological evidence that different alpha 1 adrenoceptor subtypes mediate contracti... 8564247 - Effects of u46619 on contractions to 5-ht, sumatriptan and methysergide in canine coron... 8181037 - Endothelial function of human gastroepiploic artery in comparison with saphenous vein. 22394037 - Low density lipoprotein size in relation to carotid intima-media thickness in coronary ... 3156887 - Reversible optic neuropathy due to carotid-cavernous fistula. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 23 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1994 Apr |
Date Detail:
|
Created Date: 1994-07-08 Completed Date: 1994-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 576-83 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, University Hospital of Lund, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Arteries
/
chemistry Azepines / pharmacology Coronary Vessels / chemistry*, physiology Endothelins / immunology*, metabolism Humans Immunohistochemistry Indoles / pharmacology Receptors, Endothelin / analysis*, antagonists & inhibitors Vasoconstriction / physiology Veins / chemistry |
| Chemical | |
Reg. No./Substance:
|
0/Azepines; 0/Endothelins; 0/Indoles; 0/Receptors, Endothelin; 142375-60-8/FR 139317 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chronotropic cardiac effects of falipamil in conscious dogs: interactions with the autonomic nervous...
Next Document: Efficacy of angiotensin-converting enzyme inhibition and AT1 receptor blockade on cardiac pump perfo...