| Localization of eIF4A-III in the nucleolus and splicing speckles is an indicator of plant stress. | |
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MedLine Citation:
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PMID: 20514231 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The mechanisms of long-term adaptation to low oxygen environment are quite well studied, but little is known about the sensing of oxygen shortage, the signal transduction and the shortterm effects of hypoxia in plant cells. We have found that an RNA helicase eIF4A-III, a putative component of the Exon Junction Complex, rapidly changes its pattern of localisation in the plant nucleus under hypoxic conditions. In normal cell growth conditions GFPeIF4A-III was mainly nucleoplasmic, but in hypoxia stress conditions it moved to the nucleolus and splicing speckles. This transition occurred within 15-20 min in Arabidopsis culture cells and seedling root cells, but took more than 2 h in tobacco BY-2 culture cells. Inhibition of respiration, transcription or phosphorylation in cells and ethanol treatment had similar effects to hypoxia. The most likely consequence is that a certain mRNA population will remain bound to the eIF4A-III and other mRNA processing proteins, rather than being transported from the nucleus to the cytoplasm, and thus its translation will be suspended. |
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Authors:
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Olga A Koroleva; John W S Brown; Pete J Shaw |
Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Plant signaling & behavior Volume: 4 ISSN: 1559-2324 ISO Abbreviation: Plant Signal Behav Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-08-02 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 101291431 Medline TA: Plant Signal Behav Country: United States |
Other Details:
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Languages: eng Pagination: 1148-51 Citation Subset: - |
Affiliation:
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Department of Cell Biology, John Innes Centre, Colney, Norwich, UK. |
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Descriptor/Qualifier:
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| Comments/Corrections | |
Comment On:
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Plant Cell. 2009 May;21(5):1592-606
[PMID:
19435936
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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