| Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila. | |
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MedLine Citation:
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PMID: 16139215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During asymmetric cell division, protein determinants are segregated into one of the two daughter cells. The Numb protein acts as a segregating determinant during both mouse and Drosophila development. In flies, Numb localizes asymmetrically and is required for cell-fate specification in the central and peripheral nervous systems, as well as during muscle and heart development. Whether its asymmetric segregation is important to the performance of these functions is not firmly established. Here, we demonstrate that Numb acts both in a localization-dependent and in a localization-independent manner. We have generated numb mutants that affect only the asymmetric localization of the protein during mitosis. We demonstrate that asymmetric segregation of Numb into one of the two daughter cells is absolutely essential for cell-fate specification in the Drosophila peripheral nervous system. Numb localization is also essential in MP2 neuroblasts in the central nervous system and during muscle development. Surprisingly, in dividing ganglion mother cells or during heart development, Numb function is independent of its ability to segregate asymmetrically in mitosis. Our results suggest that two classes of asymmetric cell division exist, each with different requirements for asymmetric inheritance of cell-fate determinants. |
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Authors:
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Sheetal Bhalerao; Daniela Berdnik; Tibor Török; Juergen A Knoblich |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current biology : CB Volume: 15 ISSN: 0960-9822 ISO Abbreviation: Curr. Biol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-05 Completed Date: 2006-03-23 Revised Date: 2008-10-15 |
Medline Journal Info:
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Nlm Unique ID: 9107782 Medline TA: Curr Biol Country: England |
Other Details:
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Languages: eng Pagination: 1583-90 Citation Subset: IM |
Affiliation:
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Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Dr. Bohr Gasse 3-5, 1030 Vienna, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology* Cell Division / physiology* Drosophila / embryology*, genetics Drosophila Proteins / metabolism* Immunohistochemistry Juvenile Hormones / metabolism* Muscles / cytology, metabolism Mutation / genetics Peripheral Nervous System / cytology, metabolism* Protein Transport / physiology Transgenes / genetics |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Juvenile Hormones; 0/numb protein, Drosophila |
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