Document Detail


Localization of chat-like immunoreactivity in the vestibular endorgans of the rat.
MedLine Citation:
PMID:  8071146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vertebrates acetylcholine (ACh) has been generally considered as a neurotransmitter of the vestibular efferent system. The precise localization and innervation of the cholinergic nerve endings in the vestibular sensory periphery is still unknown. We examined choline acetyltransferase (ChAT)-like immunoreactivity in all five endorgans of the rat vestibule with light and electron microscopy using a modified pre-embedding immunostaining technique. The results were: (1) ChAT-like immunoreactivity was widespread in all five endorgans of the vestibule and confined to the vesiculated efferent nerve endings. (2) Two types of ChAT-like immunostained nerve endings can be identified according to their size and innervation pattern: a large nerve ending and a small--middle size one. (3) Vestibular endorgans differ in their ChAT-like immunoreactivity: staining is dense in the macula of the utricule and the three ampullary cristae, but less so in the macula of the saccule. (4) We found also a regional difference of the ChAT-like immunostaining in ampullary crista. ChAT-like immunostained nerve endings were predominant in the periphery close to the semilunar plane, and less in density in the central area. These findings demonstrate that ACh is a major neurotransmitter in the vestibular efferent system.
Authors:
W J Kong; G Egg; B Hussl; H Spoendlin; A Schrott-Fischer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hearing research     Volume:  75     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-09-27     Completed Date:  1994-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  191-200     Citation Subset:  IM; S    
Affiliation:
Department of Otolaryngology, University of Innsbruck, Austria.
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MeSH Terms
Descriptor/Qualifier:
Animals
Choline O-Acetyltransferase / metabolism*
Female
Hair Cells, Auditory / enzymology,  ultrastructure
Immunohistochemistry
Male
Microscopy, Electron
Nerve Endings / enzymology*,  ultrastructure
Rats
Rats, Sprague-Dawley
Vestibule, Labyrinth / innervation*,  ultrastructure
Chemical
Reg. No./Substance:
EC 2.3.1.6/Choline O-Acetyltransferase

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