Document Detail

Localization of cerebral functional deficits in treatment-naive, first-episode schizophrenia using resting-state fMRI.
MedLine Citation:
PMID:  19963069     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Spontaneous low-frequency fluctuations (LFF) in the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal have been shown to reflect cerebral spontaneous neural activity, and the present study attempts to explore the functional changes in the regional brain in patients with schizophrenia using the amplitude of the BOLD signals. METHODS: A total of 66 treatment-na?ve, first-episode schizophrenia (FES) patients and 66 normal age- and sex-matched controls were recruited. Resting-state fMRIs were obtained using a gradient-echo echo-planar imaging sequence. The amplitude of LFF (ALFF) was calculated using REST software. Voxel-based analysis of the ALFF maps between control and patient groups was performed with twos-sample t-tests using SPM2. RESULTS: Compared to the controls, the FES group showed significantly decreased ALFF in the medial prefrontal lobe (MPFC) and significant increases in the ALFF in the left and right putamen. Significant positive correlations were observed between ALFF values in the bilateral putamen in both the patient and control groups. CONCLUSIONS: Alterations of the ALFF in the MPFC and putamen in FES observed in the present study suggest that the functional abnormalities of those areas are at an early stage of the disease.
Xiao-Qi Huang; Su Lui; Wei Deng; Raymond C K Chan; Qi-Zhu Wu; Li-Jun Jiang; Jun-Ran Zhang; Zhi-Yun Jia; Xiu-Li Li; Fei Li; Long Chen; Tao Li; Qi-Yong Gong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-04
Journal Detail:
Title:  NeuroImage     Volume:  49     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2901-6     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Inc. All rights reserved.
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, West China School of Medicine, Chengdu, 610041, China.
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MeSH Terms
Brain / physiopathology*
Brain Mapping / methods*
Magnetic Resonance Imaging / methods*
Schizophrenia / diagnosis*,  physiopathology*
Young Adult

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