Document Detail

Localization of cellular retinoid-binding proteins in human cervical intraepithelial neoplasia and invasive carcinoma.
MedLine Citation:
PMID:  1329518     Owner:  NLM     Status:  MEDLINE    
Cellular retinoic acid-binding protein (CRABP) and cellular retinol-binding protein (CRBP) were localized in biopsies of normal squamous epithelium, cervical intraepithelial neoplasia (CIN), and invasive squamous cell cancer of the cervix uteri by immunohistochemistry. In both the normal stratified squamous epithelium of the exocervix and low-grade CIN, CRABP I was present predominantly in the basal layer of the epithelium. The more superficial, differentiated cell layers lacked immunoreactive protein. In high-grade CIN (CIN2-3), the distribution of CRABP I was altered. Immunoreactive CRABP I was detected in all layers of high-grade CIN. In squamous cell carcinoma of the cervix, CRABP I was detected in cells throughout the tumor but was minimal in cells demonstrating squamous differentiation. In contrast to CRABP I, CRBP was diffusely present throughout the cervical epithelium irrespective of the state of differentiation or the presence of disease.
P Hillemanns; L Tannous-Khuri; J P Koulos; D Talmage; T C Wright
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of pathology     Volume:  141     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-03     Completed Date:  1992-11-03     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  973-80     Citation Subset:  AIM; IM    
Department of Pathology, Columbia University, New York, NY 10032.
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MeSH Terms
Carcinoma, Squamous Cell / metabolism*
Carrier Proteins / metabolism*
Cervix Uteri / metabolism
Middle Aged
Neoplasm Proteins / metabolism
Receptors, Retinoic Acid
Retinol-Binding Proteins / metabolism*
Retinol-Binding Proteins, Cellular
Tretinoin / metabolism
Uterine Cervical Neoplasms / metabolism*
Grant Support
Reg. No./Substance:
0/Carrier Proteins; 0/Neoplasm Proteins; 0/Receptors, Retinoic Acid; 0/Retinol-Binding Proteins; 0/Retinol-Binding Proteins, Cellular; 302-79-4/Tretinoin

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