Document Detail

Localization of calcitonin gene-related peptide in human esophageal Langerhans cells.
MedLine Citation:
PMID:  1985053     Owner:  NLM     Status:  MEDLINE    
Previously undescribed calcitonin gene-related peptide-immunoreactive intraepithelial cells were seen in specimens of esophageal mucosa obtained by biopsy or surgical resection from 14 individuals. These calcitonin gene-related peptide-immunoreactive cells were sparsely seen in normal mucosa but increased markedly in esophagitis. They were inaccessible to routine histological stains, but osmication showed them as dendritic forms resembling Langerhans cells of the skin. Their cytological identity was determined with immunocytochemical tests for human antigenic markers such as Ia, HLA-DR, and OKT6 for Langerhans cells, Leu-M5 and Leu-M3 for intraepithelial macrophages, CD3 and TCR-1 for T-lymphocytes, Leu-14 for B-lymphocytes, S-100 for Merkel cells, and chromogranin for amine precursor uptake and decarboxylation cells. Double localization showed that calcitonin gene-related peptide immunoreactivity colocalized with Ia, HLA-DR, and OKT6 but not with the other markers. These studies show that intraepithelial Langerhans cells in the esophageal mucosa contain calcitonin gene-related peptide, which may serve as an immunomodulator.
C Singaram; A Sengupta; C Stevens; S J Spechler; R K Goyal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  100     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-02-01     Completed Date:  1991-02-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  560-3     Citation Subset:  AIM; IM    
Gastroenterology Division, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts.
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MeSH Terms
Calcitonin Gene-Related Peptide / analysis*
Esophagitis / metabolism,  pathology
Esophagitis, Peptic / metabolism,  pathology
Esophagus / metabolism*
Langerhans Cells / metabolism*
Mucous Membrane / metabolism
Grant Support
Reg. No./Substance:
83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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