| Localization of basic fibroblast growth factor in bovine adrenal chromaffin cells. | |
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MedLine Citation:
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PMID: 7891078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have investigated basic fibroblast growth factor (FGF-2) localization in and release from isolated bovine adrenal chromaffin cells. In contrast to previous reports, we found no evidence of fibroblast growth factor (FGF) storage in catecholamine-containing chromaffin granules. Subcellular fractionation studies did not show enrichment of FGF-2 immunoreactivity in granules, and cholinergic stimulation failed to release FGF-2 into the medium. Our results suggest that adrenal chromaffin cells resemble other FGF-2-synthesizing cell types with respect to FGF storage and secretion. |
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Authors:
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S C Bieger; A W Henkel; K Unsicker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurochemistry Volume: 64 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-04-18 Completed Date: 1995-04-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1521-7 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, University of Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Medulla
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cytology,
metabolism* Animals Blotting, Northern Blotting, Western Cattle Chromaffin System / cytology, metabolism* Fibroblast Growth Factor 2 / metabolism* Immunohistochemistry Microscopy, Immunoelectron Stimulation, Chemical Subcellular Fractions / metabolism Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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103107-01-3/Fibroblast Growth Factor 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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