| Localization of aldosterone-producing adrenocortical adenomas: significance of adrenal venous sampling. | |
| | |
MedLine Citation:
|
PMID: 18250558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Accurate localization of aldosterone-producing adenoma (APA) is essential for the treatment of primary aldosteronism (PA). In order to confirm the clinical usefulness of adrenal venous sampling (AVS), we retrospectively studied 87 cases of PA in whom AVS was conducted. We collected right and left adrenal venous effluents simultaneously before and after adrenocorticotropic hormone (ACTH) stimulation for measurements of aldosterone concentration (A) and cortisol concentration (C). Based on AVS results, we judged 66 cases as having unilateral aldosterone hypersecretion and the remaining 21 cases as having no apparent laterality. Of the above 66 subjects, 61 underwent laparoscopic removal of the adrenal gland through a retroperitoneal approach. The presence of APA was histopathologically confirmed, and blood pressure decreased significantly with normalization of plasma aldosterone concentration (PAC) in all cases. The receiver operator characteristics (ROC) curve analysis between the operated and no-apparent-laterality groups revealed that the ratio of A/C on the higher side to A/C on the lower side (A/C ratio) after ACTH stimulation is a useful index, with a cutoff value of 2.6, a sensitivity of 0.98 and a specificity of 1.0. The ROC curve analysis between the APA side and contralateral side within the operated patients revealed that the cutoff value of A was 1,340 ng/dL, with a sensitivity of 0.92 and a specificity of 1.00. Our results indicate the usefulness of simultaneous AVS and ACTH stimulation for localizing APA. |
| | |
Authors:
|
Fumitoshi Satoh; Takaaki Abe; Masayuki Tanemoto; Masahiro Nakamura; Michiaki Abe; Akira Uruno; Ryo Morimoto; Akihiro Sato; Kei Takase; Shigeto Ishidoya; Yoichi Arai; Takashi Suzuki; Hironobu Sasano; Tadashi Ishibashi; Sadayoshi Ito |
Related Documents
:
|
639368 - The effect of an angiotensin antagonist (saralasin) on arterial pressure and plasma ald... 19797978 - Improving vascular function in hypertension: potential benefits of combination therapy ... 6995018 - Renin-angiotensin-aldosterone system in arterial hypertension. 17606858 - Effects of fenofibrate on cardiac remodeling in aldosterone-induced hypertension. 2559668 - Cardioprotective effect of trimetazidine and nifedipine in guinea-pig hearts subjected ... 17780008 - Fruit storage at subatmospheric pressures. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 30 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2008-02-05 Completed Date: 2008-02-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
|
Languages: eng Pagination: 1083-95 Citation Subset: IM |
Affiliation:
|
Department of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, Sendai, Japan. fsatoh@mail.tains.tohoku.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenoma
/
blood,
diagnosis*,
pathology Adrenal Cortex Neoplasms / blood, diagnosis*, pathology Adrenocorticotropic Hormone / diagnostic use Adult Aged Aldosterone / blood*, physiology Blood Specimen Collection / methods* Female Humans Hydrocortisone / blood* Male Middle Aged ROC Curve Sensitivity and Specificity Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
|
50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 9002-60-2/Adrenocorticotropic Hormone |
| Comments/Corrections | |
Comment In:
|
Hypertens Res. 2007 Nov;30(11):1009-10
[PMID:
18250546
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevalence and lifestyle characteristics of hypertensive patients with metabolic syndrome followed a...
Next Document: Add-on effect of bedtime dosing of the alpha(1)-adrenergic receptor antagonist doxazosin on morning ...