Document Detail

Localization of transforming growth factor beta3 in squamous metaplasia of the porcine oviduct: a case report.
MedLine Citation:
PMID:  19144038     Owner:  NLM     Status:  In-Process    
Squamous metaplasia of the oviduct epithelium is a rare disorder of reproductive organs. We noted squamous metaplasia of the oviduct epithelium in a sow routinely slaughtered at day 2 of the oestrous cycle. Expression of transforming growth factor beta3 (TGF beta3) in the metaplastic epithelia was evaluated by immunohistochemistry, because TGF beta3 appears to play a key role as regulator of a variety of tissue remodelling events. Our results show that TGF beta3 immunostaining was specifically localized to foci of squamous metaplasia of the epithelial linings. Non-metaplastic epithelial cells of the oviduct were not immunostained with anti-TGF beta3 antibody. At the subcellular level, TGF beta3-labelled cells occasionally showed signs of apoptotic cell death. It is concluded that signals produced by TGF beta3 in metaplastic lesions of the oviduct are potentially involved in pathophysiological processes.
M Steffl; M Schweiger; W M Amselgruber
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-01-07
Journal Detail:
Title:  Reproduction in domestic animals = Zuchthygiene     Volume:  45     ISSN:  1439-0531     ISO Abbreviation:  Reprod. Domest. Anim.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015668     Medline TA:  Reprod Domest Anim     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  734-6     Citation Subset:  IM    
Department of Anatomy and Physiology of Domestic Animals, University of Hohenheim, Stuttgart, Germany.
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