| Localised proton MR spectroscopy of brain metabolism changes in vegetative patients. | |
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MedLine Citation:
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PMID: 9189874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined 14 vegetative brain-injured patients with proton magnetic resonance single-volume spectroscopy (1H MRS) at 1.5 T to establish whether there were changes in relative concentrations of N-acetyl aspartate (NAA), choline (Cho) and creatine (CR) metabolites from those found in healthy brains. Spectra were obtained from two different (2 x 2 x 2 cm) volumes of interest in the left and in the right frontal cortex, normal on MRI. All spectra revealed abnormalities compared with normal spectra obtained from age-matched control subjects. Values outside the normal range for at least one of the metabolite ratios were observed in all patients. Cho/Cr was markedly higher and NAA/Cho and NAA/Cr were markedly lower than in the control subjects. At different times six patients regained awareness and the ability to obey commands, and four were re-examined; changes in metabolite ratios were observed, which were different in individual patients. The NAA/Cho ratio reaches statistical significance in discriminating between the patients with a poor outcome (death or prolonged vegetative state) and those who regained awareness; the dividing line appears to be at a value of about 1.6. |
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Authors:
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R Ricci; G Barbarella; P Musi; P Boldrini; C Trevisan; N Basaglia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroradiology Volume: 39 ISSN: 0028-3940 ISO Abbreviation: Neuroradiology Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-07-24 Completed Date: 1997-07-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: GERMANY |
Other Details:
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Languages: eng Pagination: 313-9 Citation Subset: IM |
Affiliation:
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Servizio di Neuroradiologia, Ospedale Bellaria, Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aspartic Acid / analogs & derivatives, analysis Brain / metabolism* Brain Injuries / complications Child Child, Preschool Choline / analysis Creatine / analysis Female Humans Magnetic Resonance Spectroscopy* Male Persistent Vegetative State / etiology, metabolism* Prognosis Time Factors |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
| Comments/Corrections | |
Comment In:
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Neuroradiology. 1998 Mar;40(3):194
[PMID:
9561527
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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