| Localisation of prostaglandin F2 alpha and E2 binding sites in the human eye. | |
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MedLine Citation:
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PMID: 1327095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostaglandin F2 alpha reduces intraocular pressure possibly by increasing uveoscleral outflow. To further understand the mechanism of its action binding sites for prostaglandin F2 alpha and, for comparison, prostaglandin E2 were localised in sections of human cadaveric eyes using an in vitro ligand-binding technique and autoradiography. Specific binding sites for both prostaglandin F2 alpha and E2 were co-localised at a high level in the areas of the ciliary muscles and iris sphincter muscles, and at a lower level in the iris epithelium and the retina. The results suggest that prostaglandin F2 alpha and also prostaglandin E2, could modulate uveoscleral outflow by binding to their receptors located on the ciliary muscles and inducing their relaxation. |
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Authors:
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T Matsuo; M S Cynader |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 76 ISSN: 0007-1161 ISO Abbreviation: Br J Ophthalmol Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-10-29 Completed Date: 1992-10-29 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 210-3 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of British Columbia, Vancouver, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Binding Sites Ciliary Body / chemistry Eye / chemistry* Humans Iris / chemistry Male Middle Aged Receptors, Prostaglandin / analysis* Receptors, Prostaglandin E Retina / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Prostaglandin; 0/Receptors, Prostaglandin E; 0/prostaglandin F2alpha receptor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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