Document Detail

Localisation of prostaglandin F2 alpha and E2 binding sites in the human eye.
MedLine Citation:
PMID:  1327095     Owner:  NLM     Status:  MEDLINE    
Prostaglandin F2 alpha reduces intraocular pressure possibly by increasing uveoscleral outflow. To further understand the mechanism of its action binding sites for prostaglandin F2 alpha and, for comparison, prostaglandin E2 were localised in sections of human cadaveric eyes using an in vitro ligand-binding technique and autoradiography. Specific binding sites for both prostaglandin F2 alpha and E2 were co-localised at a high level in the areas of the ciliary muscles and iris sphincter muscles, and at a lower level in the iris epithelium and the retina. The results suggest that prostaglandin F2 alpha and also prostaglandin E2, could modulate uveoscleral outflow by binding to their receptors located on the ciliary muscles and inducing their relaxation.
T Matsuo; M S Cynader
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  76     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-10-29     Completed Date:  1992-10-29     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  210-3     Citation Subset:  IM    
Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Binding Sites
Ciliary Body / chemistry
Eye / chemistry*
Iris / chemistry
Middle Aged
Receptors, Prostaglandin / analysis*
Receptors, Prostaglandin E
Retina / chemistry
Reg. No./Substance:
0/Receptors, Prostaglandin; 0/Receptors, Prostaglandin E; 0/prostaglandin F2alpha receptor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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