| Localisation of the gene for Hunter syndrome on the long arm of X chromosome. | |
| | |
MedLine Citation:
|
PMID: 2878868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The localisation of the gene for Hunter syndrome (MPS II) has been studied in 11 families using 12 polymorphic DNA markers, one on the short arm and the remaining 11 located at various points on the long arm of the X chromosome. Lod scores for seven probes were uniformly negative for all values of theta; positive scores at values of theta = 0.10 or more were obtained for the five probes located most distally on the long arm (52A, F9C, DX13, St14-1, F8C). Current data suggest the most likely order of the loci to be: 52A, F9C, Hunter, DX13, St14-1, F8C-qter; the Hunter locus may thus be close to that for the fragile site at Xq27. |
| | |
Authors:
|
M Upadhyaya; M Sarfarazi; J S Bamforth; N S Thomas; I Oberle; I Young; P S Harper |
Related Documents
:
|
7151308 - Interstitial de novo deletion of the long arm of chromosome 5: mapping of 5q bands asso... 17947158 - Liquid-fueled actuation for an anthropomorphic upper extremity prosthesis. 2978118 - Markedly increased platelet membrane fluidity in down syndrome with a (14q, 21q) transl... 806438 - The location of the nucleolus organizer regions in drosophila hydei. 8494038 - Method for sequential staining of gtl-banded metaphases with fluorescent-labeled chromo... 11066078 - Chromosome imbalances in familial gliomas detected by comparative genomic hybridization. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Human genetics Volume: 74 ISSN: 0340-6717 ISO Abbreviation: Hum. Genet. Publication Date: 1986 Dec |
Date Detail:
|
Created Date: 1987-02-11 Completed Date: 1987-02-11 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7613873 Medline TA: Hum Genet Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 391-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chromosome Banding Chromosome Mapping DNA / genetics Female Genetic Markers Humans Linkage (Genetics)* Male Mucopolysaccharidosis II* / genetics* Pedigree Polymorphism, Restriction Fragment Length X Chromosome* |
| Chemical | |
Reg. No./Substance:
|
0/Genetic Markers; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Portal venous flow in response to acute beta-blocker and vasodilatatory treatment in patients with l...
Next Document: Associations between restriction fragment length polymorphisms detected with a probe for human 21-hy...