Document Detail


Localisation of the gene for Hunter syndrome on the long arm of X chromosome.
MedLine Citation:
PMID:  2878868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The localisation of the gene for Hunter syndrome (MPS II) has been studied in 11 families using 12 polymorphic DNA markers, one on the short arm and the remaining 11 located at various points on the long arm of the X chromosome. Lod scores for seven probes were uniformly negative for all values of theta; positive scores at values of theta = 0.10 or more were obtained for the five probes located most distally on the long arm (52A, F9C, DX13, St14-1, F8C). Current data suggest the most likely order of the loci to be: 52A, F9C, Hunter, DX13, St14-1, F8C-qter; the Hunter locus may thus be close to that for the fragile site at Xq27.
Authors:
M Upadhyaya; M Sarfarazi; J S Bamforth; N S Thomas; I Oberle; I Young; P S Harper
Related Documents :
7151308 - Interstitial de novo deletion of the long arm of chromosome 5: mapping of 5q bands asso...
17947158 - Liquid-fueled actuation for an anthropomorphic upper extremity prosthesis.
2978118 - Markedly increased platelet membrane fluidity in down syndrome with a (14q, 21q) transl...
806438 - The location of the nucleolus organizer regions in drosophila hydei.
8494038 - Method for sequential staining of gtl-banded metaphases with fluorescent-labeled chromo...
11066078 - Chromosome imbalances in familial gliomas detected by comparative genomic hybridization.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  74     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-02-11     Completed Date:  1987-02-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  391-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chromosome Banding
Chromosome Mapping
DNA / genetics
Female
Genetic Markers
Humans
Linkage (Genetics)*
Male
Mucopolysaccharidosis II* / genetics*
Pedigree
Polymorphism, Restriction Fragment Length
X Chromosome*
Chemical
Reg. No./Substance:
0/Genetic Markers; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Portal venous flow in response to acute beta-blocker and vasodilatatory treatment in patients with l...
Next Document:  Associations between restriction fragment length polymorphisms detected with a probe for human 21-hy...