Document Detail

Localisation of the gene for Hunter syndrome on the long arm of X chromosome.
MedLine Citation:
PMID:  2878868     Owner:  NLM     Status:  MEDLINE    
The localisation of the gene for Hunter syndrome (MPS II) has been studied in 11 families using 12 polymorphic DNA markers, one on the short arm and the remaining 11 located at various points on the long arm of the X chromosome. Lod scores for seven probes were uniformly negative for all values of theta; positive scores at values of theta = 0.10 or more were obtained for the five probes located most distally on the long arm (52A, F9C, DX13, St14-1, F8C). Current data suggest the most likely order of the loci to be: 52A, F9C, Hunter, DX13, St14-1, F8C-qter; the Hunter locus may thus be close to that for the fragile site at Xq27.
M Upadhyaya; M Sarfarazi; J S Bamforth; N S Thomas; I Oberle; I Young; P S Harper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  74     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-02-11     Completed Date:  1987-02-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  391-8     Citation Subset:  IM    
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MeSH Terms
Chromosome Banding
Chromosome Mapping
DNA / genetics
Genetic Markers
Linkage (Genetics)*
Mucopolysaccharidosis II* / genetics*
Polymorphism, Restriction Fragment Length
X Chromosome*
Reg. No./Substance:
0/Genetic Markers; 9007-49-2/DNA

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