| Localisation of eIF4A-III in the nucleolus and splicing speckles is an indicator of plant stress. | |
| | |
MedLine Citation:
|
PMID: 19855185 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The mechanisms of long-term adaptation to low oxygen environment are quite well studied, but little is known about the sensing of oxygen shortage, the signal transduction and the short-term effects of hypoxia in plant cells. We have found that an RNA helicase eIF4A-III, a putative component of the Exon Junction Complex, rapidly changes its pattern of localisation in the plant nucleus under hypoxic conditions. In normal cell growth conditions GFP-eIF4A-III was mainly nucleoplasmic, but in hypoxia stress conditions it moved to the nucleolus and splicing speckles. This transition occurred within 15-20 min in Arabidopsis culture cells and seedling root cells, but took more than 2 h in tobacco BY-2 culture cells. Inhibition of respiration, transcription or phosphorylation in cells and ethanol treatment had similar effects to hypoxia. The most likely consequence is that a certain mRNA population will remain bound to the eIF4A-III and other mRNA processing proteins, rather than being transported from the nucleus to the cytoplasm, and thus its translation will be suspended. |
| | |
Authors:
|
Olga A Koroleva; John W S Brown; Peter J Shaw |
Related Documents
:
|
8613735 - Role of ventrolateral medulla catecholamine cells in hypothalamic neuroendocrine cell r... 20107925 - Oxygen tension modulates neurite outgrowth in pc12 cells through a mechanism involving ... 18601145 - Cho cell responses to low oxygen: regulation of oxygen consumption and sensitization to... 17558805 - Effects of polycyclic aromatic hydrocarbon-containing oil mixtures on generation of rea... 7749325 - The genetics of cell cycle checkpoints. 7907115 - Radiosensitivity in ataxia-telangiectasia: anomalies in radiation-induced cell cycle de... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2009-12-25 |
Journal Detail:
|
Title: Plant signaling & behavior Volume: 4 ISSN: 1559-2324 ISO Abbreviation: Plant Signal Behav Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101291431 Medline TA: Plant Signal Behav Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Cell Biology, John Innes Centre, Colney, Norwich, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 3D tomography reveals connections between the phagophore and endoplasmic reticulum.
Next Document: Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies.