Document Detail

Local versus systemic mechanisms underlying supervised exercise training for intermittent claudication.
MedLine Citation:
PMID:  18319355     Owner:  NLM     Status:  MEDLINE    
The mechanisms by which exercise training improves intermittent claudication remain unclear. In this article, the effects of local and systemic physiological factors on improved exercise tolerance after a supervised exercise program in claudicants are investigated. A total of 60 patients were randomized to 3 months of supervised exercise followed by 3 months of unsupervised exercise, or to exercise advice alone (control). Supervised exercise increased both pain-free and maximal walking distances. Heart rate during submaximal exercise and resting mean arterial pressure were lower after supervised exercise at 6 months. Serum lactate at maximum claudication increased significantly after 3 months in the supervised exercise group but this change had resolved by 6 months. Symptomatic improvement was accompanied by modest reductions in mean arterial pressure and submaximal heart rate on exercise. Increased serum lactate at maximum claudication subsequently declined despite continued improvement in walking distance, suggesting local adaptations to improve efficiency of muscle oxygen delivery and/or utilization.
Andrew Hr Stewart; Frank Ct Smith; Roger N Baird; Peter M Lamont
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2008-03-04
Journal Detail:
Title:  Vascular and endovascular surgery     Volume:  42     ISSN:  1538-5744     ISO Abbreviation:  Vasc Endovascular Surg     Publication Date:    2008 Aug-Sep
Date Detail:
Created Date:  2008-08-27     Completed Date:  2008-12-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136421     Medline TA:  Vasc Endovascular Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  314-20     Citation Subset:  IM    
Department of Vascular Surgery, Bristol Royal Infirmary, Bristol, United Kingdom.
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MeSH Terms
Biological Markers / blood
Blood Pressure
Exercise Therapy*
Exercise Tolerance*
Heart Rate
Intermittent Claudication / metabolism,  physiopathology,  therapy*
Lactic Acid / blood
Middle Aged
Muscle, Skeletal / metabolism,  physiopathology
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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