Document Detail


Local versus diffuse recurrences of meningiomas: factors correlated to the extent of the recurrence.
MedLine Citation:
PMID:  18257472     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study is to evaluate the factors correlated with the different patterns (local, peripheral and diffuse) of meningioma recurrence. MATERIAL AND METHODS: 55 patients with benign (WHO I) meningiomas which recurred after seemingly complete removal were reviewed; 40 (Group I) had local or peripheral recurrences (< 3 cm from the initial dural attachment) and 15 (Group II) had distant and diffuse recurrences. Patient age and sex, tumor location, interval of recurrence, tumor shape, type of brain-tumor interface, histological subtype, mitotic index (MI) and progesterone receptor (PR) expression of the initial tumor, histological WHO Grade of the recurrent tumor and patient outcome were analyzed and correlated with the pattern of recurrence. RESULTS: Flat-shaped meningiomas with large dural attachment showed a significantly higher rate of diffuse recurrences than round tumors, whereas the brain-tumor interface and the tumor location were not relevant (excepting the lack of convexity meningiomas in the group of diffuse tumors). There were no significant differences of histology, MI and PR expression of the initial tumor and histological grade of the recurrent tumor between the two groups. CONCLUSIONS: The different patterns of meningioma recurrences (local, peripheral, diffuse) are not correlated with the tumor location and histology and do not represent a different biological tumor progression. We agree that most unexpected extensive recurrences result from a more extensive microscopic dural involvement.
Authors:
F Maiuri; R Donzelli; G Mariniello; M L Del Basso De Caro; A Colella; C Peca; P Vergara; G Pettinato
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neuropathology     Volume:  27     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-02-08     Completed Date:  2008-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Affiliation:
Department of Neurological Sciences, Section of Neurosurgery, Federico II University, Naples, Italy. frmaiuri@unina.it
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MeSH Terms
Descriptor/Qualifier:
Dura Mater / pathology
Female
Humans
Immunohistochemistry
Male
Meningeal Neoplasms / metabolism,  pathology*,  surgery
Meningioma / metabolism,  pathology*,  surgery
Middle Aged
Neoplasm Recurrence, Local / pathology*

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