Document Detail

Local vascular CO2 reactivity in the infant brain assessed by functional MRI.
MedLine Citation:
PMID:  7491189     Owner:  NLM     Status:  MEDLINE    
The local cerebral vascular response to hyperventilation was investigated in five distressed, intubated infants by means of a T2 sensitive gradient-echo MRI technique at 1.5 T. In one preterm infant, the MR signal change during hyperventilation was sparse. In four term infants, the mean MR signal of the brain slice investigated decreased by 1.2-2.6% per kPa change in PCO2 as a reflection of decreased cerebral blood flow during hyperventilation. Pixel-wise analysis revealed absence of vascular response in the basal ganglia, the thalamus or in the occipital region. In two adult controls, who hyperventilated voluntarily, the vascular reactivity was homogeneously distributed predominantly over the grey matter. The experiments demonstrate that local impairment of vascular CO2 reactivity in the distressed infant brain can be detected by T2 sensitive gradient-echo MRI, which is also known as functional MRI.
P B Toft; H Leth; H C Lou; O Pryds; B Peitersen; O Henriksen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric radiology     Volume:  25     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  1995  
Date Detail:
Created Date:  1996-01-04     Completed Date:  1996-01-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  420-4     Citation Subset:  IM    
Danish Research Centre of Magnetic Resonance, Hvidovre, Denmark.
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MeSH Terms
Asphyxia Neonatorum / physiopathology*
Brain / blood supply*,  physiopathology
Carbon Dioxide / physiology*
Infant, Newborn
Lactates / metabolism
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy
Regional Blood Flow
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide

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