Document Detail

Local sclerotherapy with polydocanol (Aethoxysklerol®) for the treatment of Epistaxis in Rendu-Osler-Weber or Hereditary Hemorrhagic Telangiectasia (HHT): 15 years of experience.
MedLine Citation:
PMID:  22469609     Owner:  NLM     Status:  MEDLINE    
Hereditary Haemorrhagic Telangiectasia or Rendu-Osler-Weber syndrome is a rare autosomal dominant vascular disease characterized by mucocutaneous and gastrointestinal telangiectases and localized arteriovenous malformations in lung, brain and liver. Epistaxis, due to rupture of telangiectases of the nasal mucosa, is the most frequent clinical manifestation, leading in many cases to severe impairment of the quality of life in the patients. Though several treatments have been used to reduce epistaxis, none have been completely effective, with the exception of polydocanol (Aethoxysklerol®) in submucosal or subpericondrial injections, which was first presented in 2000 with very good results. After fifteen years using polydocanol in submucosal injections on 45 patients and with nearly 300 injections, we have observed that in 95% of all cases, their nose bleeds improved with respect to frequency and quantity without any important side effects. There was just one case of septal perforation, another with increased septal perforation, and one patient who suffered from dizziness and blurred vision for a few minutes. In this paper the results obtained using this technique over a fifteen-year period will be presented and evaluated.
Darío Morais; Teresa Millás; Roberto Zarrabeitia; Luisa M Botella; Ana Almaraz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rhinology     Volume:  50     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-03     Completed Date:  2012-06-25     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  80-6     Citation Subset:  IM    
Service of Otorhinolarngology, Valladolid University Hospital, Valladolid, Spain.
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MeSH Terms
Aged, 80 and over
Epistaxis / complications,  therapy*
Middle Aged
Polyethylene Glycols / therapeutic use*
Sclerosing Solutions / therapeutic use*
Telangiectasia, Hereditary Hemorrhagic / complications*
Young Adult
Reg. No./Substance:
0/Polyethylene Glycols; 0/Sclerosing Solutions; 9002-92-0/polidocanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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